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Literature summary for 1.2.1.3 extracted from

  • Sapag, A.; Tampier, L.; Valle-Prieto, A.; Quintanilla, M.E.; Moncada, C.; Israel, Y.
    Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats (2003), Pharmacogenetics, 13, 509-515.
    View publication on PubMed
Search for more literature for 1.2.1.3

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.041
-
 NAD+ enzyme from phenotype Aldh2(1)/Aldh2(3) Rattus norvegicus
0.041
-
 NAD+ enzyme from phenotype Aldh2(3)/Aldh2(3) Rattus norvegicus
0.043
-
 NAD+ enzyme from phenotype Aldh2(1)/Aldh2(1) Rattus norvegicus
0.132
-
 NAD+ enzyme from phenotype Aldh2(2)/Aldh2(2) Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetaldehyde + NAD+ + H2O Rattus norvegicus mutations in Aldh2 strongly segregate with the phenotypes of low and high alcohol consumption and with kinetic differences in ALDH2, suggesting that pharmacogenetic differences affect voluntary alcohol consumption. Bases mutated in the coding region suggest that aldh2(2) in low drinkers is ancestral to the coding changes of either aldh2(1) or aldh2(3), which segregate with higher ethanol consumption acetate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O mutations in Aldh2 strongly segregate with the phenotypes of low and high alcohol consumption and with kinetic differences in ALDH2, suggesting that pharmacogenetic differences affect voluntary alcohol consumption. Bases mutated in the coding region suggest that aldh2(2) in low drinkers is ancestral to the coding changes of either aldh2(1) or aldh2(3), which segregate with higher ethanol consumption Rattus norvegicus acetate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ALDH2
-
 Rattus norvegicus
ALDH2(1)
-
 Rattus norvegicus
ALDH2(2)
-
 Rattus norvegicus
ALDH2(3)
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus