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Literature summary for 1.2.1.26 extracted from

  • Adams, E.; Rosso, G.
    alpha-Ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes (1967), J. Biol. Chem., 242, 1802-1814.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-Hydroxy-alpha-ketoglutaric semialdehyde
-
Pseudomonas sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
Glutaric semialdehyde
-
Pseudomonas sp.
0.05 0.1 2,5-dioxopentanoate
-
Pseudomonas sp.
0.1
-
NADP+
-
Pseudomonas sp.
0.5569
-
NAD+
-
Pseudomonas sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
115000
-
sucrose density gradient centrifugation Pseudomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,5-dioxopentanoate + NAD(P)+ + H2O Pseudomonas sp.
-
2-oxoglutarate + NAD(P)H
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
53
-
-
Pseudomonas sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,5-dioxopentanoate + NAD(P)+ + H2O
-
Pseudomonas sp. 2-oxoglutarate + NAD(P)H
-
?
2,5-dioxopentanoate + NAD+ + H2O
-
Pseudomonas sp. 2-oxoglutarate + NADH + H+
-
r
glutaric semialdehyde + NADP+ + H2O
-
Pseudomonas sp. glutarate + NADPH
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
2,5-dioxopentanoate + NADP+ Pseudomonas sp.

pH Range

pH Minimum pH Maximum Comment Organism
5.2
-
not active below, 2,5-dioxopentanoate + NADP+ Pseudomonas sp.