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Literature summary for 1.2.1.24 extracted from

  • Koh, Y.S.; Joo, C.N.; Choi, S.Y.; Kim, D.S.
    Purification and properties of succinic semialdehyde dehydrogenase from Lumbricus rubellus (1994), Korean Biochem. J., 27, 75-79.
No PubMed abstract available
Search for more literature for 1.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid)
-
 Lumbricus rubellus
Disulfiram
-
 Lumbricus rubellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 succinate semialdehyde
-
 Lumbricus rubellus
0.019
-
 benzaldehyde
-
 Lumbricus rubellus
0.033
-
 p-nitrobenzaldehyde
-
 Lumbricus rubellus
0.061
-
 NAD+
-
 Lumbricus rubellus
0.85
-
 propionaldehyde
-
 Lumbricus rubellus
0.9
-
 acetaldehyde
-
 Lumbricus rubellus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
 2 * 56000, SDS-PAGE Lumbricus rubellus
120000
-
 gel filtration Lumbricus rubellus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate semialdehyde + NAD+ + H2O Lumbricus rubellus enzyme may play an important role, not only in metabolizing succinate semialdehyde but also in oxidation of aromatic aldehydes in the soil environment succinate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Lumbricus rubellus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Lumbricus rubellus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.56
-
-
 Lumbricus rubellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
 Lumbricus rubellus acetate + NADH + H+
-
 ?
benzaldehyde + NAD+ + H2O
-
 Lumbricus rubellus benzoate + NADH + H+
-
 ?
p-nitrobenzaldehyde + NAD+ + H2O
-
 Lumbricus rubellus p-nitrobenzoate + NADH
-
 ?
propionaldehyde + NAD+ + H2O
-
 Lumbricus rubellus propionate + NADH
-
 ?
succinate semialdehyde + NAD+ + H2O
-
 Lumbricus rubellus succinate + NADH
-
 ?
succinate semialdehyde + NAD+ + H2O enzyme may play an important role, not only in metabolizing succinate semialdehyde but also in oxidation of aromatic aldehydes in the soil environment Lumbricus rubellus succinate + NADH
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 56000, SDS-PAGE Lumbricus rubellus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
 Lumbricus rubellus

pH Range

pH Minimum pH Maximum Comment Organism
8.5 10 pH 8.5: about 45% of maximal activity, pH 10.0: about 70% of maximal activity Lumbricus rubellus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Lumbricus rubellus