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Literature summary for 1.2.1.23 extracted from

  • Jellum, E.
    Metabolism of the ketoaldehyde 2-keto-3-deoxyglucose (1968), Biochim. Biophys. Acta, 165, 357-363.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
NAD+
-
Ovis aries
1.2
-
2-dehydro-3-deoxy-D-glucos
-
Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-dehydro-3-deoxy-D-glucose + NAD+ + H2O Rattus norvegicus
-
2-dehydro-3-deoxy-D-gluconate + NADH + H+
-
?
2-dehydro-3-deoxy-D-glucose + NAD+ + H2O Ovis aries
-
2-dehydro-3-deoxy-D-gluconate + NADH + H+
-
?
methylglyoxal + NAD+ + H2O Rattus norvegicus i.e. pyruvaldehyde pyruvate + NADH + H+
-
?
methylglyoxal + NAD+ + H2O Ovis aries i.e. pyruvaldehyde pyruvate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using treatment with acetone, ammonium sulfate fractionation, and gel filtration on Sephadex G-25 Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
liver
-
Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-dehydro-3-deoxy-D-glucose + NAD+ + H2O
-
Rattus norvegicus 2-dehydro-3-deoxy-D-gluconate + NADH + H+
-
?
2-dehydro-3-deoxy-D-glucose + NAD+ + H2O
-
Ovis aries 2-dehydro-3-deoxy-D-gluconate + NADH + H+
-
?
2-oxoaldehydes + NAD+ + H2O enzyme from sheep or rat liver also active with NADP+, see also EC 1.2.1.49 Rattus norvegicus 2-oxo acids + NADH
-
?
2-oxoaldehydes + NAD+ + H2O enzyme from sheep or rat liver also active with NADP+, see also EC 1.2.1.49 Ovis aries 2-oxo acids + NADH
-
?
methylglyoxal + NAD+ + H2O i.e. pyruvaldehyde Rattus norvegicus pyruvate + NADH + H+
-
?
methylglyoxal + NAD+ + H2O i.e. pyruvaldehyde Ovis aries pyruvate + NADH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus
NAD+
-
Ovis aries
NADP+ enzyme from sheep or rat liver, see also EC 1.2.1.49 Rattus norvegicus
NADP+ enzyme from sheep or rat liver, see also EC 1.2.1.49 Ovis aries