Literature summary for 1.2.1.20 extracted from

Park, S.; Kim, E.; Noh, W.; Park, H.; Oh, Y.; Lee, S.; Song, B.; Jegal, J.; Lee, S.
Metabolic engineering of Escherichia coli for the production of 5-aminovalerate and glutarate as C5 platform chemicals (2013), Metab. Eng., 16, 42-47 .

Cloned(Commentary)

Cloned (Comment)	Organism
gene davD, recombinant expression in Escherichia coli strain W3110, coexpression with Pseudomonas putida gene gabT, encoding 5-aminovalerate aminotransferase, and davA and davB genes encoding delta-aminovaleramidase and lysine 2-monooxygenase, respectively. The recombinant Escherichia coli WL3110 strain expressingthe davAB and gabTD genes is cultured in a medium containing D-glucose, L-lysine, and 2-oxoglutarate, and produces glutarate	Pseudomonas putida

Cloned (Comment)

Organism

gene davD, recombinant expression in Escherichia coli strain W3110, coexpression with Pseudomonas putida gene gabT, encoding 5-aminovalerate aminotransferase, and davA and davB genes encoding delta-aminovaleramidase and lysine 2-monooxygenase, respectively. The recombinant Escherichia coli WL3110 strain expressingthe davAB and gabTD genes is cultured in a medium containing D-glucose, L-lysine, and 2-oxoglutarate, and produces glutarate

Pseudomonas putida

Protein Variants

Protein Variants	Comment	Organism
additional information	metabolic engineering strategies for the production of 5-aminovalerate from L-lysine in vivo synthesized from glucose in Escherichia coli by amplifying metabolic fluxes and activities, e.g. enzyme glutarate semialdehyde dehydrogenase, and by removing repressions and feedback inhibitions involved in L-lysine metabolism, oevrview	Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glutarate semialdehyde + NAD+ + H2O	Pseudomonas putida	-	glutarate + NADH + 2 H+	-	?
glutarate semialdehyde + NAD+ + H2O	Pseudomonas putida ATCC 47054	-	glutarate + NADH + 2 H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas putida	Q88RC0	-	-
Pseudomonas putida ATCC 47054	Q88RC0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutarate semialdehyde + NAD+ + H2O	-	Pseudomonas putida	glutarate + NADH + 2 H+	-	?
glutarate semialdehyde + NAD+ + H2O	-	Pseudomonas putida ATCC 47054	glutarate + NADH + 2 H+	-	?

Synonyms

Synonyms	Comment	Organism
davD	-	Pseudomonas putida
glutarate semialdehyde dehydrogenase	-	Pseudomonas putida

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Pseudomonas putida

General Information

General Information	Comment	Organism
metabolism	the enzyme is involved in the metabolic pathways for the production of 5-aminovalerate and glutarate from L-lysine	Pseudomonas putida