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Literature summary for 1.2.1.19 extracted from

  • Xie, K.; Wu, C.; Chi, Z.; Wang, J.; Wang, H.; Wei, Y.; Shao, X.; Xu, F.
    Enhancement of gamma-aminobutyric acid (GABA) and other health-promoting metabolites in germinated broccoli by mannose treatment (2021), Sci. Hortic., 276, 109706 .
No PubMed abstract available
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-aminobutyraldehyde + NAD+ + H2O Brassica oleracea var. italica
-
 4-aminobutanoate + NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Brassica oleracea var. italica
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sprout
-
 Brassica oleracea var. italica
-
stem
-
 Brassica oleracea var. italica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutyraldehyde + NAD+ + H2O
-
 Brassica oleracea var. italica 4-aminobutanoate + NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
4-aminobutyraldehyde dehydrogenase
-
 Brassica oleracea var. italica
ABALDH
-
 Brassica oleracea var. italica

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Brassica oleracea var. italica

Expression

Organism Comment Expression
Brassica oleracea var. italica significantly lower 4-aminobutyraldehyde dehydrogenase (ABALDH) activity is observed in mannose-treated sprouts than in the control except for the eighth day down
Brassica oleracea var. italica mannose treatment enhances the activity of 4-aminobutyraldehyde dehydrogenase (ABALDH) after the eighth day up

General Information

General Information Comment Organism
metabolism mannose treatment improves glutamate (Glu) content and the activity of diamine oxidase (DAO), and reduces gamma-aminobutyric acid transaminase (GABA-T) activity, which enriches GABA biosynthesis. Mannose treatment enhances the activities of diamine oxidase (DAO), polyamine oxidase (PAO), and 4-aminobutyraldehyde dehydrogenase (ABALDH), and increases the conversion rate of free polyamine. Mannose treatment may boost the accumulation of GABA in sprouting broccoli, via enhancing GAD activity and providing more glutamate. GABA is degraded by GABA-T, which uses pyruvate or glyoxalate as amino acceptor to convert GABA into succinate semialdehyde (SSA). SSA dehydrogenase catalyzes the irreversible NADP+-dependent oxidation of SSA to succinate. GABA-T activity is significantly reduced in broccoli sprouts under mannose treatment in late growth stage. Polyamines are mainly about free Put, free Spd and free Spm. Arginine is converted to fPut via alternative arginase and ornithine decarboxylase. fPut in turn is converted to fSpd and fSpm via spermidine synthase and spermine synthase, respectively. PAO is responsible for catalyzing the oxidation or back-conversion of fSpm and fSpd, resulting in the formation of 1,3-diaminopropane, and their degradation to 4-aminobutyraldehyde. DAO catalyze the degradation of fPut to 4-aminobutyraldehyde, which in turn are converted to GABA by ABALDH Brassica oleracea var. italica