Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.19 extracted from

  • Testore, G.; Cravanzola, C.; Bedino, S.
    Aldehyde dehydrogenase from rat intestinal mucosa: purification and characterization of an isozyme with high affinity for gamma-aminobutyraldehyde (1999), Int. J. Biochem. Cell Biol., 31, 777-786.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cationic buffers
-
Rattus norvegicus
ion-exchange resins
-
Rattus norvegicus
NADH
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
4-Aminobutyraldehyde 250 mM phosphate preparation, constant substrate 1 mM NAD+ Rattus norvegicus
0.054
-
acetaldehyde 250 mM phosphate preparation, constant substrate 1 mM NAD+ Rattus norvegicus
0.081
-
4-Aminobutyraldehyde 400 mM phosphate preparation, constant substrate 1 mM NAD+ Rattus norvegicus
0.252
-
Succinic semialdehyde 400 mM phosphate preparation, constant substrate 1 mM NAD+ Rattus norvegicus
0.285
-
Betaine aldehyde 250 mM phosphate preparation, constant substrate 1 mM NAD+ Rattus norvegicus
5.428
-
Succinic semialdehyde 250 mM phosphate preparation, constant substrate 1 mM NAD+ Rattus norvegicus
6.9
-
acetaldehyde 400 mM phosphate preparation, constant substrate 1 mM NAD+ Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
2 * 52000, SDS-PAGE Rattus norvegicus
112000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-aminobutanal + NAD+ + H2O Rattus norvegicus involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid 4-aminobutanoate + NADH + H+
-
?
4-aminobutanal + NAD+ + H2O Rattus norvegicus Wistar- involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid 4-aminobutanoate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Wistar-strain
-
Rattus norvegicus Wistar-
-
Wistar-strain
-

Purification (Commentary)

Purification (Comment) Organism
using column chromatography on hydroxylapatite, precipitation with ammonium sulfate, column chromatography on Sephacryl S-300, Phenyl-superose, 5'-AMP-Sepharose and hydroxylapatite Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
intestinal mucosa
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
4°C, 250 mM phosphate, pH 6.8, in the presence of 4 mM dithiothreitol, activity decreases by 20-30% after 7 days, freezing resultes in complete inactivation Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanal + NAD+ + H2O
-
Rattus norvegicus 4-aminobutanoate + NADH + H+
-
?
4-aminobutanal + NAD+ + H2O involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid Rattus norvegicus 4-aminobutanoate + NADH + H+
-
?
4-aminobutanal + NAD+ + H2O
-
Rattus norvegicus Wistar- 4-aminobutanoate + NADH + H+
-
?
4-aminobutanal + NAD+ + H2O involved in the metabolism of biogenic amines and in the synthesis of 4-aminobutyric acid Rattus norvegicus Wistar- 4-aminobutanoate + NADH + H+
-
?
acetaldehyde + NAD+ + H2O
-
Rattus norvegicus acetate + NADH + H+
-
?
acetaldehyde + NAD+ + H2O
-
Rattus norvegicus Wistar- acetate + NADH + H+
-
?
betaine aldehyde + NAD+ + H2O
-
Rattus norvegicus betaine + NADH + H+
-
?
betaine aldehyde + NAD+ + H2O
-
Rattus norvegicus Wistar- betaine + NADH + H+
-
?
succinate semialdehyde + NAD+
-
Rattus norvegicus succinate + NADH + H+
-
?
succinate semialdehyde + NAD+
-
Rattus norvegicus Wistar- succinate + NADH + H+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 52000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.5
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus