KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.083 | - |
4-Aminobutyraldehyde | - |
Rattus norvegicus | |
0.48 | - |
NAD+ | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutanal + NAD+ + H2O | Rattus norvegicus | synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain | 4-aminobutanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | Rattus norvegicus Wistar- | synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain | 4-aminobutanoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar-strain | - |
Rattus norvegicus Wistar- | - |
Wistar-strain | - |
Purification (Comment) | Organism |
---|---|
using ammonium sulfate fractionation and column chromatography on DEAE-cellulose, AMP-Sepharose, Sephadex G-200 and NAD+-Sepharose | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.2 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, several months | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-aminopropanal + NAD+ + H2O | 17% the rate of 4-aminobutyraldehyde reduction | Rattus norvegicus | 3-aminopropanoate + NADH + H+ | - |
? | |
3-aminopropanal + NAD+ + H2O | 17% the rate of 4-aminobutyraldehyde reduction | Rattus norvegicus Wistar- | 3-aminopropanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | - |
Rattus norvegicus | 4-aminobutanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain | Rattus norvegicus | 4-aminobutanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | - |
Rattus norvegicus Wistar- | 4-aminobutanoate + NADH + H+ | - |
? | |
4-aminobutanal + NAD+ + H2O | synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain | Rattus norvegicus Wistar- | 4-aminobutanoate + NADH + H+ | - |
? | |
additional information | very low activity with: succinate semialdehyde | Rattus norvegicus | ? | - |
? | |
additional information | very low activity with benzaldehyde, propionaldehyde | Rattus norvegicus | ? | - |
? | |
additional information | very low activity with: succinate semialdehyde | Rattus norvegicus Wistar- | ? | - |
? | |
additional information | very low activity with benzaldehyde, propionaldehyde | Rattus norvegicus Wistar- | ? | - |
? | |
succinate semialdehyde + NAD+ | 24% the rate of 4-aminobutyraldehyde reduction | Rattus norvegicus | succinate + NADH + H+ | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
-20 | - |
stable over several months | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.9 | 8.5 | at pH 6.9: about 30% of activity maximum, at pH 8.5: about 65% of activity maximum | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |