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Literature summary for 1.17.4.4 extracted from

  • Watanabe, K.P.; Saengtienchai, A.; Tanaka, K.D.; Ikenaka, Y.; Ishizuka, M.
    Comparison of warfarin sensitivity between rat and bird species (2010), Comp. Biochem. Physiol. C, 152, 114-119.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7- and 10-hydroxylated warfarin Anas platyrhynchos
warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, and 8-hydroxylated warfarin Bubo scandiacus
warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, and 8-hydroxylated warfarin Bubo virginianus
warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, 8- and 10-hydroxylated warfarin Gallus gallus
warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, 8- and 10-hydroxylated warfarin Rattus norvegicus
warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, and 8-hydroxylated warfarin Struthio camelus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1658
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone pH 7.4, 37°C Gallus gallus
0.1761
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone pH 7.4, 37°C Rattus norvegicus
0.1875
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone pH 7.4, 37°C Struthio camelus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Gallus gallus
-
-
microsome
-
Rattus norvegicus
-
-
microsome
-
Anas platyrhynchos
-
-
microsome
-
Struthio camelus
-
-
microsome
-
Bubo scandiacus
-
-
microsome
-
Bubo virginianus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Gallus gallus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Rattus norvegicus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Anas platyrhynchos
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Struthio camelus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Bubo scandiacus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Bubo virginianus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Gallus gallus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Rattus norvegicus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Anas platyrhynchos
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Struthio camelus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Bubo scandiacus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Bubo virginianus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r

Organism

Organism UniProt Comment Textmining
Anas platyrhynchos
-
-
-
Bubo scandiacus
-
-
-
Bubo virginianus
-
-
-
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-
Struthio camelus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially by microsome preparation by ultracentrifugation Rattus norvegicus
partially by microsome preparation by ultracentrifugation Anas platyrhynchos
partially by microsome preparation by ultracentrifugation Struthio camelus
partially by microsome preparation by ultracentrifugation Bubo scandiacus
partially by microsome preparation by ultracentrifugation Bubo virginianus
partially, microsome preparation by ultracentrifugation Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-
liver
-
Rattus norvegicus
-
liver
-
Anas platyrhynchos
-
liver
-
Struthio camelus
-
liver
-
Bubo scandiacus
-
liver
-
Bubo virginianus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Gallus gallus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Rattus norvegicus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Anas platyrhynchos 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Struthio camelus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Bubo scandiacus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Bubo virginianus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Gallus gallus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Rattus norvegicus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Anas platyrhynchos 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Struthio camelus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Bubo scandiacus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Bubo virginianus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r

Synonyms

Synonyms Comment Organism
vitamin K 2,3-epoxide reductase
-
Gallus gallus
vitamin K 2,3-epoxide reductase
-
Rattus norvegicus
vitamin K 2,3-epoxide reductase
-
Anas platyrhynchos
vitamin K 2,3-epoxide reductase
-
Struthio camelus
vitamin K 2,3-epoxide reductase
-
Bubo scandiacus
vitamin K 2,3-epoxide reductase
-
Bubo virginianus
VKOR
-
Gallus gallus
VKOR
-
Rattus norvegicus
VKOR
-
Anas platyrhynchos
VKOR
-
Struthio camelus
VKOR
-
Bubo scandiacus
VKOR
-
Bubo virginianus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Rattus norvegicus
37
-
-
Anas platyrhynchos
38
-
-
Struthio camelus
41
-
-
Bubo scandiacus
41
-
-
Bubo virginianus
42
-
-
Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Gallus gallus
7.4
-
assay at Rattus norvegicus
7.4
-
assay at Anas platyrhynchos
7.4
-
assay at Struthio camelus
7.4
-
assay at Bubo scandiacus
7.4
-
assay at Bubo virginianus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00028
-
warfarin pH 7.4, 37°C Rattus norvegicus
0.00064
-
warfarin pH 7.4, 38°C Struthio camelus
0.0113
-
warfarin pH 7.4, 42°C Gallus gallus

General Information

General Information Comment Organism
evolution clear difference in VKOR activity and Ki for warfarin among bird species Gallus gallus
evolution clear difference in VKOR activity and Ki for warfarin among bird species Anas platyrhynchos
evolution clear difference in VKOR activity and Ki for warfarin among bird species Struthio camelus
evolution clear difference in VKOR activity and Ki for warfarin among bird species Bubo scandiacus
evolution clear difference in VKOR activity and Ki for warfarin among bird species Bubo virginianus