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Literature summary for 1.17.3.2 extracted from

  • de Araujo, M.E.M.B.; Franco, Y.E.M.; Alberto, T.G.; Messias, M.C.F.; Leme, C.W.; Sawaya, A.C.H.F.; Carvalho, P.O.
    Kinetic study on the inhibition of xanthine oxidase by acylated derivatives of flavonoids synthesised enzymatically (2017), J. Enzyme Inhib. Med. Chem., 32, 978-985 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.3.2

Inhibitors

Inhibitors Comment Organism Structure
allopurinol 90% inhibition at 0.045 mM Bos taurus
naringin about 15% inhibition at 0.045 mM Bos taurus
naringin decanoate about 24% inhibition at 0.045 mM Bos taurus
naringin hexanoate about 15% inhibition at 0.045 mM Bos taurus
naringin laurate below 10% inhibition at 0.045 mM Bos taurus
naringin octanoate about 26% inhibition at 0.045 mM Bos taurus
naringin oleate below 10% inhibition at 0.045 mM Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten and Lineweaver-Burk kinetics Bos taurus
0.017
-
 xanthine pH 7.4, 37°C Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + NAD+ + H2O Bos taurus
-
 xanthine + NADH + H+
-
 ?
xanthine + H2O + O2 Bos taurus
-
 urate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus P80457
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Bos taurus
-
milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + NAD+ + H2O
-
 Bos taurus xanthine + NADH + H+
-
 ?
xanthine + H2O + O2
-
 Bos taurus urate + H2O2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01467
-
 pH 7.4, 37°C Bos taurus allopurinol
0.11035
-
 pH 7.4, 37°C Bos taurus naringin octanoate
0.11751
-
 pH 7.4, 37°C Bos taurus naringin decanoate