Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allopurinol | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-D-tyrosinate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-L-tyrosinate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-D-tryptophanate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-alaninate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-phenylalaninate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-tyrosinate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-(1H-inden-3-yl)-D-alaninate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-D-tyrosinate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-L-tyrosinate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-alaninate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-phenylalaninate | - |
Bos taurus | |
methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-tyrosinate | - |
Bos taurus | |
additional information | synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C, mode of XO inhibition, molecular modeling, Structure-activity relationships, overview. Molecular docking simulations of compounds methyl-(E)-(3-(2-(3,4-dihydroxyphenyl)-7-hydroxybenzofuran-4-yl)acryloyl)-L-phenylalaninate, (E)-(3-(2-(3,4-dihydroxyphenyl)-7-hydroxybenzofuran-4-yl)acryloyl)-L-phenylalanine, and (E)-(3-(2-(3,4-dimethoxyphenyl)-7-methoxybenzofuran-4-yl)acryloyl)-L-phenylalanine into the binding pocket of the bovine milk XDH/Febuxostat complex, PDB ID 1N5X | Bos taurus | |
N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-D-tyrosine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-L-tyrosine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-D-tryptophan | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-alanine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-phenylalanine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-tyrosine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-D-tyrosine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-L-tyrosine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-alanine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-phenylalanine | - |
Bos taurus | |
N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-tyrosine | - |
Bos taurus | |
salvianolic acid A | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
xanthine + H2O + O2 | Bos taurus | - |
urate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P80457 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Bos taurus | - |
milk | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
xanthine + H2O + O2 | - |
Bos taurus | urate + H2O2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00361 | - |
pH not specified in the publication, 37°C | Bos taurus | allopurinol | |
0.004 | - |
pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-D-tyrosinate | |
0.0045 | - |
pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-tyrosine | |
0.0048 | - |
pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-L-tyrosine | |
0.005 | - |
pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-D-tryptophan | |
0.00604 | - |
pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-phenylalanine | |
0.0064 | - |
pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-alanine | |
0.0083 | - |
above, pH not specified in the publication, 37°C | Bos taurus | salvianolic acid A | |
0.0099 | - |
pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-L-tyrosinate | |
0.0108 | - |
pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-alaninate | |
0.0121 | - |
pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-D-tyrosine | |
0.0135 | - |
pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-tyrosinate | |
0.0149 | - |
pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-L-phenylalaninate | |
0.0317 | - |
pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]-D-tryptophanate | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-(1H-inden-3-yl)-D-alaninate | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-D-tyrosinate | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-L-tyrosinate | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-alaninate | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-phenylalaninate | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | methyl N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-tyrosinate | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-D-tyrosine | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-3-hydroxy-L-tyrosine | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-alanine | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-phenylalanine | |
0.06 | - |
above, pH not specified in the publication, 37°C | Bos taurus | N-[(2E)-3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-4-yl]prop-2-enoyl]-L-tyrosine |