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Literature summary for 1.17.3.2 extracted from
- The potential role for xanthine oxidase inhibition in major intra-abdominal surgery (2008), World J. Surg., 32, 288-295.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| allopurinol | - |
Felis silvestris |  |
| allopurinol | - |
Homo sapiens | |
| allopurinol | - |
Mus musculus | |
| allopurinol | - |
Rattus norvegicus | |
| apigenin | - |
Homo sapiens | |
| apigenin | - |
Rattus norvegicus | |
| epicatechin | - |
Homo sapiens | |
| epicatechin | - |
Rattus norvegicus | |
| green tea extract | - |
Homo sapiens | |
| green tea extract | - |
Rattus norvegicus | |
| luteolin | - |
Homo sapiens | |
| luteolin | - |
Rattus norvegicus | |
| quercetin | - |
Homo sapiens | |
| quercetin | - |
Rattus norvegicus | |
| Tungsten | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to prevention of intestine necrosis | ? | - |
? | |
| additional information | Felis silvestris | xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in neutrophil infiltration | ? | - |
? | |
| additional information | Rattus norvegicus | xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in villar necrosis, reduced intestinal MPO levels, reduced circulating neutrophil priming and reduction in pulmonary damage, prevention of permeability changes in intestinal mucosa, reduction in length of necrotic small bowel by 60%, reduction in intestinal apoptosis and tissue MDA levels; reduction in plasma MDA levels and improvement in renal function, and improved small intestine anastomotic healing and animal survival, overview | ? | - |
? | |
| xanthine + H2O + O2 | Mus musculus | the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | Homo sapiens | the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | Rattus norvegicus | the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | Felis silvestris | the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview | urate + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Felis silvestris | - |
f. catus | - |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| small intestine | - |
Mus musculus | - |
| small intestine | - |
Homo sapiens | - |
| small intestine | - |
Rattus norvegicus | - |
| small intestine | - |
Felis silvestris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to prevention of intestine necrosis | Mus musculus | ? | - |
? | |
| additional information | xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in neutrophil infiltration | Felis silvestris | ? | - |
? | |
| additional information | xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in villar necrosis, reduced intestinal MPO levels, reduced circulating neutrophil priming and reduction in pulmonary damage, prevention of permeability changes in intestinal mucosa, reduction in length of necrotic small bowel by 60%, reduction in intestinal apoptosis and tissue MDA levels; reduction in plasma MDA levels and improvement in renal function, and improved small intestine anastomotic healing and animal survival, overview | Rattus norvegicus | ? | - |
? | |
| xanthine + H2O + O2 | production of superoxide radicals | Mus musculus | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | production of superoxide radicals | Homo sapiens | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | production of superoxide radicals | Rattus norvegicus | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | production of superoxide radicals | Felis silvestris | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview | Mus musculus | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview | Homo sapiens | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview | Rattus norvegicus | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview | Felis silvestris | urate + H2O2 | - |
? | |
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