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Literature summary for 1.17.3.2 extracted from

  • Zhao, L.; Roche, B.M.; Wessale, J.L.; Kijtawornrat, A.; Lolly, J.L.; Shemanski, D.; Hamlin, R.L.
    Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: effects of early versus delayed treatment (2008), Life Sci., 82, 495-502.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
allopurinol
-
Oryctolagus cuniculus
febuxostat a potent non-purine, selective inhibitor of the enzyme Oryctolagus cuniculus
oxypurinol active metabolite of allopurinol Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Oryctolagus cuniculus chronic enzyme inhibition by allopurinol or febuxostat cannot prevent or treat the progression of congestive heart failure induced by coronary artery ligation in rabbits, overview ?
-
?
xanthine + H2O + O2 Oryctolagus cuniculus
-
urate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
male New Zealand White rabbits
-

Source Tissue

Source Tissue Comment Organism Textmining
heart enzyme expression is increased in the failing heart Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information chronic enzyme inhibition by allopurinol or febuxostat cannot prevent or treat the progression of congestive heart failure induced by coronary artery ligation in rabbits, overview Oryctolagus cuniculus ?
-
?
xanthine + H2O + O2
-
Oryctolagus cuniculus urate + H2O2
-
?
xanthine + H2O + O2 production of superoxide radicals Oryctolagus cuniculus urate + H2O2
-
?