Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allopurinol | - |
Oryctolagus cuniculus | |
febuxostat | a potent non-purine, selective inhibitor of the enzyme | Oryctolagus cuniculus | |
oxypurinol | active metabolite of allopurinol | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Oryctolagus cuniculus | chronic enzyme inhibition by allopurinol or febuxostat cannot prevent or treat the progression of congestive heart failure induced by coronary artery ligation in rabbits, overview | ? | - |
? | |
xanthine + H2O + O2 | Oryctolagus cuniculus | - |
urate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
male New Zealand White rabbits | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | enzyme expression is increased in the failing heart | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | chronic enzyme inhibition by allopurinol or febuxostat cannot prevent or treat the progression of congestive heart failure induced by coronary artery ligation in rabbits, overview | Oryctolagus cuniculus | ? | - |
? | |
xanthine + H2O + O2 | - |
Oryctolagus cuniculus | urate + H2O2 | - |
? | |
xanthine + H2O + O2 | production of superoxide radicals | Oryctolagus cuniculus | urate + H2O2 | - |
? |