Literature summary for 1.17.3.2 extracted from

Khosravan, R.; Kukulka, M.J.; Wu, J.T.; Joseph-Ridge, N.; Vernillet, L.
The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase (2008), J. Clin. Pharmacol., 48, 1014-1024.

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Inhibitors

Inhibitors	Comment	Organism	Structure
febuxostat	i.e. 2-[3-cyano-4-(2-methylpropoxy)-phenyl]-4-methylthiazole-5-carboxylic acid, a nonpurine-selective inhibitor used for management of hyperuricemia in patients with gout, effects of age and gender on pharmacokinetics, pharmacodynamics, and safety, detailed overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
xanthine + H2O + O2	Homo sapiens	-	urate + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	female and male	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
xanthine + H2O + O2	-	Homo sapiens	urate + H2O2	-	?

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Release 2023.1 (January 2023)