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Literature summary for 1.17.3.2 extracted from

  • George, J.; Struthers, A.D.
    The role of urate and xanthine oxidase inhibitors in cardiovascular disease (2008), Cardiovasc. Ther., 26, 59-64.
    View publication on PubMed
Search for more literature for 1.17.3.2

Inhibitors

Inhibitors Comment Organism Structure
allopurinol i.e. 1, 5-dihydro-4H-pyrazolo [3, 4-d]pyrimidine-4-one, allopurinol is a substrate and a competitive inhibitor for xanthine oxidase, it binds irreversibly at the active site reducing molybdenum VI to IV, and it is used for treatment of hyperuricemia Homo sapiens
allopurinol i.e. 1, 5-dihydro-4H-pyrazolo [3, 4-d]pyrimidine-4-one, allopurinol is a substrate and a competitive inhibitor for xanthine oxidase, it binds irreversibly at the active site reducing molybdenum VI to IV, and it is used for treatment of hyperuricemia Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme inhibitors exert beneficial effect on endothelial dysfunction, mechanisms, overview, mechanism of action in cardiovascular disease, overview ?
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 ?
additional information Rattus norvegicus enzyme inhibitors exert beneficial effect on endothelial dysfunction, mechanisms, overview, mechanism of action in cardiovascular disease, overview ?
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 ?
xanthine + H2O + O2 Homo sapiens urate is involved in development of endothelial dysfunction, overview urate + H2O2
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 ?
xanthine + H2O + O2 Rattus norvegicus urate is involved in development of endothelial dysfunction, overview urate + H2O2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Rattus norvegicus
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-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
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 Homo sapiens
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endothelium
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 Rattus norvegicus
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heart
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 Homo sapiens
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heart
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
allopurinol + H2O + O2 allopurinol is a substrate and a competitive inhibitor for xanthine oxidase, it binds irreversibly at the active site reducing molybdenum VI to IV Homo sapiens oxypurinol + H2O2
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 ?
allopurinol + H2O + O2 allopurinol is a substrate and a competitive inhibitor for xanthine oxidase, it binds irreversibly at the active site reducing molybdenum VI to IV Rattus norvegicus oxypurinol + H2O2
-
 ?
additional information enzyme inhibitors exert beneficial effect on endothelial dysfunction, mechanisms, overview, mechanism of action in cardiovascular disease, overview Homo sapiens ?
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 ?
additional information enzyme inhibitors exert beneficial effect on endothelial dysfunction, mechanisms, overview, mechanism of action in cardiovascular disease, overview Rattus norvegicus ?
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 ?
xanthine + H2O + O2 urate is involved in development of endothelial dysfunction, overview Homo sapiens urate + H2O2
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 ?
xanthine + H2O + O2 urate is involved in development of endothelial dysfunction, overview Rattus norvegicus urate + H2O2
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 ?
xanthine + H2O + O2 production of superoxide radicals, mechanism of stepwise enzyme reduction during catalysis, overview Homo sapiens urate + H2O2
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 ?
xanthine + H2O + O2 production of superoxide radicals, mechanism of stepwise enzyme reduction during catalysis, overview Rattus norvegicus urate + H2O2
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 ?