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Literature summary for 1.17.3.2 extracted from

  • Tamta, H.; Kalra, S.; Thilagavathi, R.; Chakraborti, A.K.; Mukhopadhyay, A.K.
    Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase - enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different (2007), Biochemistry (Moscow), 72, 170-177.
    View publication on PubMed
Search for more literature for 1.17.3.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00046
-
 6-Thioxanthine 25°C Bos taurus
0.00047
-
 2-Thioxanthine 25°C Bos taurus
0.00088
-
 2-mercaptopurine 25°C Bos taurus
0.002
-
 6-Mercaptopurine 25°C Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + H2O + O2 Bos taurus
-
 urate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-mercaptopurine + H2O + O2 no conversion to 2-thioxanthine Bos taurus 8-hydroxy-2-mercaptopurine + H2O2
-
 ?
2-thioxanthine + H2O + O2
-
 Bos taurus 2-thiouric acid + H2O2
-
 ?
6-mercaptopurine + 2 H2O + 2 O2 a two-step reaction with 6-thioxanthine as intermediate Bos taurus 6-thiouric acid + 2 H2O2
-
 ?
6-thioxanthine + H2O + O2
-
 Bos taurus 6-thiouric acid + H2O2
-
 ?
hypoxanthine + 2 H2O + 2 O2 a two-step reaction with xanthine as intermediate, production of superoxide radicals Bos taurus urate + 2 H2O2
-
 ?
additional information nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase Bos taurus ?
-
 ?
xanthine + H2O + O2
-
 Bos taurus urate + H2O2
-
 ?
xanthine + H2O + O2 production of superoxide radicals Bos taurus urate + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
XOD
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.13
-
 6-Mercaptopurine 25°C Bos taurus
1.98
-
 2-mercaptopurine 25°C Bos taurus
2.76
-
 6-Thioxanthine 25°C Bos taurus
3.32
-
 2-Thioxanthine 25°C Bos taurus