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Literature summary for 1.17.3.2 extracted from

  • Landmesser, U.; Spiekermann, S.; Preuss, C.; Sorrentino, S.; Fischer, D.; Manes, C.; Mueller, M.; Drexler, H.
    Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease (2007), Arterioscler. Thromb. Vasc. Biol., 27, 943-948.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II Ang II substantially increases endothelial enzyme protein levels and enzyme-dependent superoxide production in cultured endothelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
allopurinol enzyme inhibition with allopurinol does not improve endothelium-dependent vasodilation before Homo sapiens
losartan in patients with coronary disease, losartan therapy reduces endothelium-bound xanthine oxidase activity likely contributing to improved endothelial function, enzyme inhibition with losartan does not improve endothelium-dependent vasodilation before Homo sapiens
oxypurinol enzyme inhibition with oxypurinol improves endothelium-dependent vasodilation before Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme and its superoxide producing activity are involved in endothelial dysfunction in atherosclerosis, overview ?
-
?
xanthine + H2O + O2 Homo sapiens
-
urate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme and its superoxide producing activity are involved in endothelial dysfunction in atherosclerosis, overview Homo sapiens ?
-
?
xanthine + H2O + O2
-
Homo sapiens urate + H2O2
-
?