Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | Ang II substantially increases endothelial enzyme protein levels and enzyme-dependent superoxide production in cultured endothelial cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allopurinol | enzyme inhibition with allopurinol does not improve endothelium-dependent vasodilation before | Homo sapiens | |
losartan | in patients with coronary disease, losartan therapy reduces endothelium-bound xanthine oxidase activity likely contributing to improved endothelial function, enzyme inhibition with losartan does not improve endothelium-dependent vasodilation before | Homo sapiens | |
oxypurinol | enzyme inhibition with oxypurinol improves endothelium-dependent vasodilation before | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme and its superoxide producing activity are involved in endothelial dysfunction in atherosclerosis, overview | ? | - |
? | |
xanthine + H2O + O2 | Homo sapiens | - |
urate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme and its superoxide producing activity are involved in endothelial dysfunction in atherosclerosis, overview | Homo sapiens | ? | - |
? | |
xanthine + H2O + O2 | - |
Homo sapiens | urate + H2O2 | - |
? |