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Literature summary for 1.17.1.4 extracted from

  • Watanabe, S.; Kounosu, Y.; Shimada, H.; Sakamoto, A.
    Arabidopsis xanthine dehydrogenase mutants defective in purine degradation show a compromised protective response to drought and oxidative stress (2014), Plant Biotechnol., 31, 173-178 .
No PubMed abstract available
Search for more literature for 1.17.1.4

Protein Variants

Protein Variants Comment Organism
additional information generation of XDH-knockdown mutants, analysis of compromised drought-stress responses of proline biosynthesis in Arabidopsis thaliana XDH-knockdown mutants, phenotype, overview Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + NAD+ + H2O Arabidopsis thaliana
-
 urate + NADH + H+
-
 ?
xanthine + NAD+ + H2O Arabidopsis thaliana Col-0
-
 urate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8GUQ8
-
-
Arabidopsis thaliana Col-0 Q8GUQ8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + NAD+ + H2O
-
 Arabidopsis thaliana urate + NADH + H+
-
 ?
xanthine + NAD+ + H2O
-
 Arabidopsis thaliana Col-0 urate + NADH + H+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction dysfunction of purine degradation is a result of knocking down the key enzyme xanthine dehydrogenase, leading to severely reduced survival of Arabidopsis thaliana under progressive drought conditions and to significantly decreased tolerance to superoxide-mediated oxidative stress. The enhanced stress sensitivity of the knockdown mutants likely results from defective stress responses, because the drought-induced accumulation of the cellular protectant proline is compromised in the knockdown plants, which also show lower mRNA levels of P5CS1, the gene encoding the rate-limiting enzyme for proline biosynthesis, DELTA1-pyrroline-5-carboxylate synthase 1 Arabidopsis thaliana
physiological function role for purine metabolites in stress responses, supporting the possible contribution of purine degradation to plant acclimation to changing environments, overview Arabidopsis thaliana