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Literature summary for 1.17.1.4 extracted from

  • Edwards, T.C.R.; Candido, E.P.M.
    Xanthine dehydrogenase from Drosophila melanogaster. A comparison of the kinetic parameters of the pure enzyme from two wild-type isoalleles differing at a putative regulatory site (1977), Mol. Gen. Genet., 154, 1-6.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
xanthine ping-pong reaction mechanism Drosophila melanogaster
0.04
-
NAD+ ping-pong reaction mechanism Drosophila melanogaster

Metals/Ions

Metals/Ions Comment Organism Structure
Mo
-
Drosophila melanogaster

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
150000
-
x * 150000, SDS-phosphate gel electrophoresis Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + NAD+ + H+ + O2- + H2O Drosophila melanogaster
-
xanthine + NADH + H2O2
-
?
xanthine + NAD+ + H2O Drosophila melanogaster
-
urate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, immunoaffinity chromatography Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + NAD+ + H+ + O2- + H2O
-
Drosophila melanogaster xanthine + NADH + H2O2
-
?
xanthine + NAD+ + H2O
-
Drosophila melanogaster urate + NADH
-
?

Subunits

Subunits Comment Organism
? x * 150000, SDS-phosphate gel electrophoresis Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Drosophila melanogaster