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Literature summary for 1.17.1.4 extracted from

  • Truglio, J.J.; Theis, K.; Leimkuhler, S.; Rappa, R.; Rajagopalan, K.V.; Kisker, C.
    Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus (2002), Structure, 10, 115-125.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
2.7 A resolution, direct coordination of alloxanthine to the molybdenum via a nitrogen atom Rhodobacter capsulatus

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxypyrazolo(3,4-d)pyrimidine i.e. allopurinol; inhibition by direct coordination of the reaction product alloxanthine, to the molybdenum via a nitrogen atom Rhodobacter capsulatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + NAD+ + H2O Rhodobacter capsulatus
-
xanthine + NADH + H+
-
?
xanthine + NAD+ + H2O Rhodobacter capsulatus
-
urate + NADH
-
?
xanthine + O2 + H2O Rhodobacter capsulatus
-
urate + O2- + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Rhodobacter capsulatus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Rhodobacter capsulatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxypyrazolo(3,4-d)pyrimidine + nitroblue tetrazolium + H2O i.e. allopurinol Rhodobacter capsulatus 4,6-dihydroxypyrazolo(3,4-d)pyrimidine + reduced nitroblue tetrazolium
-
?
hypoxanthine + NAD+ + H2O
-
Rhodobacter capsulatus xanthine + NADH + H+
-
?
xanthine + NAD+ + H2O
-
Rhodobacter capsulatus urate + NADH
-
?
xanthine + O2 + H2O
-
Rhodobacter capsulatus urate + O2- + 2 H+
-
?

Cofactor

Cofactor Comment Organism Structure
additional information
-
Rhodobacter capsulatus