Protein Variants | Comment | Organism |
---|---|---|
E126A | the mutation causes a decrease in the Fe2+/O2 stoichiometry from about 3 to about 2 for the first 48 Fe2+ added to the protein | Escherichia coli |
E130A | the mutation causes a decrease in the Fe2+/O2 stoichiometry from about 3 to about 2 for the first 48 Fe2+ added to the protein | Escherichia coli |
E17A | the mutation increases the Fe2+/O2 stoichiometry from about 3 to about 4 compared to the wild type enzyme | Escherichia coli |
E49A | the mutation causes a decrease in the Fe2+/O2 stoichiometry from about 3 to about 2 for the first 48 Fe2+ added to the protein | Escherichia coli |
E94A | the mutation increases the Fe2+/O2 stoichiometry from about 3 to about 4 compared to the wild type enzyme | Escherichia coli |
H53A | the mutation increases the Fe2+/O2 stoichiometry from about 3 to about 4 compared to the wild type enzyme | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fe(II) + H2O2 + H2O | Escherichia coli | - |
[FeO(OH)] + H+ | - |
? | |
Fe(II) + O2 + H2O | Escherichia coli | - |
[FeO(OH)] + H+ + H2O2 | - |
? | |
Fe(II) + O2 + H2O | Escherichia coli | overall reaction | [FeO(OH)] + H+ + H2O2 | - |
? | |
additional information | Escherichia coli | although H2O2 is a product of dioxygen reduction in FtnA and oxidation occurs with a stoichiometry of Fe2+/O2 about 3:1 most of the H2O2 produced is consumed in subsequent reactions with a 2:1 Fe2+/H2O2 stoichiometry, thus suppressing hydroxyl-radical formation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fe(II) + H2O2 + H2O | - |
Escherichia coli | [FeO(OH)] + H+ | - |
? | |
Fe(II) + O2 + H2O | - |
Escherichia coli | [FeO(OH)] + H+ + H2O2 | - |
? | |
Fe(II) + O2 + H2O | overall reaction | Escherichia coli | [FeO(OH)] + H+ + H2O2 | - |
? | |
additional information | although H2O2 is a product of dioxygen reduction in FtnA and oxidation occurs with a stoichiometry of Fe2+/O2 about 3:1 most of the H2O2 produced is consumed in subsequent reactions with a 2:1 Fe2+/H2O2 stoichiometry, thus suppressing hydroxyl-radical formation | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FtnA | - |
Escherichia coli |
nonheme bacterial ferritin | - |
Escherichia coli |