Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Homo sapiens | |
4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Mus musculus | |
additional information | design and synthesis of piperidine-aryl urea-based stearoyl-CoA desaturase1 inhibitors, overview | Homo sapiens | |
additional information | design and synthesis of piperidine-aryl urea-based stearoyl-CoA desaturase1 inhibitors, overview | Mus musculus | |
N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide | - |
Homo sapiens | |
N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide | - |
Mus musculus | |
N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide | - |
Homo sapiens | |
N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide | - |
Mus musculus | |
N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide | - |
Homo sapiens | |
N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide | - |
Mus musculus | |
N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide | - |
Homo sapiens | |
N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | Mus musculus | - |
oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | Homo sapiens | - |
oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Mus musculus | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Homo sapiens | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCD1 | - |
Mus musculus |
SCD1 | - |
Homo sapiens |
stearoyl-CoA desaturase 1 | - |
Mus musculus |
stearoyl-CoA desaturase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ferrocytochrome b5 | - |
Mus musculus | |
ferrocytochrome b5 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000004 | - |
below | Mus musculus | 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.000004 | - |
below | Mus musculus | 4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.000004 | - |
below | Mus musculus | 4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.000006 | - |
- |
Mus musculus | 4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.000008 | - |
- |
Mus musculus | 4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide | |
0.000008 | - |
- |
Mus musculus | 4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.00001 | - |
- |
Mus musculus | 4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide | |
0.00001 | - |
- |
Mus musculus | N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide | |
0.000017 | - |
- |
Mus musculus | N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide | |
0.000018 | - |
- |
Homo sapiens | 4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.00002 | - |
- |
Mus musculus | 4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.00003 | - |
- |
Homo sapiens | 4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.000037 | - |
- |
Homo sapiens | 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.000058 | - |
- |
Homo sapiens | 4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.000059 | - |
- |
Homo sapiens | N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide | |
0.000081 | - |
- |
Mus musculus | 4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.000098 | - |
- |
Mus musculus | 4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.00011 | - |
- |
Homo sapiens | 4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide | |
0.00012 | - |
- |
Homo sapiens | N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide | |
0.00015 | - |
- |
Homo sapiens | 4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.00027 | - |
- |
Homo sapiens | 4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.00033 | - |
- |
Mus musculus | 4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.00036 | - |
- |
Homo sapiens | 4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide | |
0.00037 | - |
- |
Mus musculus | N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide | |
0.00059 | - |
- |
Mus musculus | 4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide | |
0.00068 | - |
- |
Homo sapiens | 4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.00081 | - |
- |
Mus musculus | 4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide | |
0.0019 | - |
- |
Homo sapiens | 4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.004 | - |
- |
Homo sapiens | N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide | |
0.0071 | - |
- |
Homo sapiens | 4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide | |
0.0075 | - |
- |
Homo sapiens | 4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide | |
0.0097 | - |
- |
Homo sapiens | 4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
0.01 | - |
above | Mus musculus | N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide | |
0.01 | - |
above | Homo sapiens | N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide |