Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | EB1285, a non-1alpha-hydroxylated vitamin D analogue prodrug of EB1089, shows about 20% ketoconazole-sensitive transcription activation of the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | Homo sapiens | the enzyme hydroxylates the major circulating form of vitamin D to the active systemic hormone 1,25(OH)2D3, local production of 1,25(OH)2D3 appears to occur also at other sites where 1alpha-hydroxylase is expressed for autocrine/paracrine regulation, overview | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15528 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
breast cancer cell | the enzyme expression is reduced in breast cancer cell specimen compared to healthy breast tissue | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
parathyroid gland | enzyme expression in secondary hyperparathyroidism | Homo sapiens | - |
renal tubule | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | - |
Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D + NADPH + O2 | the enzyme hydroxylates the major circulating form of vitamin D to the active systemic hormone 1,25(OH)2D3, local production of 1,25(OH)2D3 appears to occur also at other sites where 1alpha-hydroxylase is expressed for autocrine/paracrine regulation, overview | Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
1alpha-hydroxylase | - |
Homo sapiens |
25-hydroxyvitamin D3 1alpha-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |