Crystallization (Comment) | Organism |
---|---|
truncated, soluble hHO-1 variant, consisting of 233 amino acids, in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone, sitting-drop vapor diffusion, room temperature, 0.412 mM heme-HO-1 complex in 20 mM potassium phosphate is mixed with inhibitor in a 1:3 molar ratio, the reservoir solution contains100 mM HEPES, pH 7.5, 2.00-2.28 M ammonium sulfate, and 0.8-1.1% 1,6-hexanediol, X-ray diffraction structure determination and analysis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R,S)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol | - |
Rattus norvegicus | |
(R,S)-1-(4,5-diphenyl-1H-imidazol-1-yl)-4-phenyl-2-butanol | - |
Rattus norvegicus | |
(R,S)-4-phenyl-1-(1H-1,2,3-triazol-1-yl)-2-butanol | - |
Rattus norvegicus | |
(R,S)-4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol | - |
Rattus norvegicus | |
(R,S)-4-phenyl-1-(1H-tetrazol-1-yl)-2-butanol | - |
Rattus norvegicus | |
(R,S)-4-phenyl-1-(2H-tetrazol-2-yl)-2-butanol | - |
Rattus norvegicus | |
(R,S)-4-phenyl-1-(4-phenyl-1H-imidazol-1-yl)-2-butanol | - |
Rattus norvegicus | |
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-1,2,3-triazole | - |
Rattus norvegicus | |
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole | - |
Rattus norvegicus | |
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-tetrazole | - |
Rattus norvegicus | |
1-((2-phenylethyl)-1,3-dioxolan-2-yl)methyl-1H-imidazole | - |
Rattus norvegicus | |
1-((2-phenylethyl-1,3-dioxolan-2-yl)methyl)-4,5-diphenyl-1H-imidazole | - |
Rattus norvegicus | |
1-((2-phenylethyl-1,3-dioxolan-2-yl)methyl)-4-phenyl-1H-imidazole | - |
Rattus norvegicus | |
1-(1H-benzimidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(1H-benzotriazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(2-methyl-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(2-methylsulfonyl-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(2-methylthio-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(2-nitro-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(2H-benzotriazol-2-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(3,5-dibromo-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(3,5-diphenyl-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(3-methylsulfonyl-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(3-methylthio-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(3-nitro-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(3-phenyl-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(4,5-dichloro-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(4,5-dicyano-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(4,5-diphenyl-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(4-bromo-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(4-nitro-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(5-bromo-1H-imidazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(5-methylsulfonyl-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(5-methylsulfonyl-1H-tetrazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(5-methylsulfonyl-2H-tetrazol-2-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(5-methylthio-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(5-methylthio-1H-tetrazol-1-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-(5-methylthio-2H-tetrazol-2-yl)-4-phenyl-2-butanone | - |
Rattus norvegicus | |
1-bromo-4-phenyl-2-butanone | - |
Rattus norvegicus | |
2-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-2H-1,2,3-triazole | - |
Rattus norvegicus | |
2-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-2H-tetrazole | - |
Rattus norvegicus | |
2-methylthio-1H-imidazole | - |
Rattus norvegicus | |
3,5-dibromo-1H-1,2,4-triazole | - |
Rattus norvegicus | |
3,5-diphenyl-1H-1,2,4-triazole | - |
Rattus norvegicus | |
3-phenyl-1H-1,2,4-triazole | - |
Rattus norvegicus | |
4-phenyl-1-(1H-1,2,3-triazol-1-yl)-2-butanone | - |
Rattus norvegicus | |
4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone | the inhibitor binds at the distal pocket through the coordination of heme iron by the N4 in the triazole mpiety, whereas the phenyl group is stabilized by hydrophobic interactions from residues within the binding pocket, binding structure, modelling, overview | Rattus norvegicus | |
4-phenyl-1-(1H-pyrazol-1-yl)-2-butanone | - |
Rattus norvegicus | |
4-phenyl-1-(1H-tetrazol-1-yl)-2-butanone | - |
Rattus norvegicus | |
4-phenyl-1-(2-phenyl-1H-imidazol-1-yl)-2-butanone | - |
Rattus norvegicus | |
4-phenyl-1-(2H-1,2,3-triazol-2-yl)-2-butanone | - |
Rattus norvegicus | |
4-phenyl-1-(2H-tetrazol-2-yl)-2-butanone | - |
Rattus norvegicus | |
4-phenyl-1-(4-phenyl-1H-imidazol-1-yl)-2-butanone | - |
Rattus norvegicus | |
4-phenyl-1-(5-phenyl-1H-tetrazol-1-yl)-2-butanone | - |
Rattus norvegicus | |
4-phenyl-1-(5-phenyl-2H-tetrazol-2-yl)-2-butanone | - |
Rattus norvegicus | |
azalanstat | - |
Rattus norvegicus | |
dimethyl 1-(2-oxo-4-phenylbut-1-yl)-1H-imidazole-4,5-dicarboxylate | - |
Rattus norvegicus | |
ethyl (1-(2-oxo-4-phenylbutyl)-1H-tetrazol-5-yl)acetate | - |
Rattus norvegicus | |
ethyl (2-(2-oxo-4-phenylbutyl)-2H-tetrazol-5-yl)acetate | - |
Rattus norvegicus | |
ethyl 1-(2-oxo-4-phenylbut-1-yl)-1H-imidazole-2-carboxylate | - |
Rattus norvegicus | |
methyl 1-(2-oxo-4-phenylbut-1-yl)-1H-1,2,4-triazole-3-carboxylate | - |
Rattus norvegicus | |
methyl 1-(2-oxo-4-phenylbut-1-yl)-1H-1,2,4-triazole-5-carboxylate | - |
Rattus norvegicus | |
methyl 1-(2-oxo-4-phenylbut-1-yl)-1H-imidazole-4-carboxylate | - |
Rattus norvegicus | |
methyl 1-(2-oxo-4-phenylbut-1-yl)-1H-imidazole-5-carboxylate | - |
Rattus norvegicus | |
additional information | design and synthesis, and inhibitory potency of a series of 2-oxy-substituted 1-azolyl-4-phenylbutanes, inhibition of heme oxygenase-1 and heme oxygenase-2, overview | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Sprague-Dawley | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
spleen | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | heme oxygenase activity in rat spleen and brain microsomal fractions is determined by the quantitation of CO formed from the degradation of methemalbumin, i.e. heme complexed with albumin | Rattus norvegicus | ? | - |
? | |
additional information | heme oxygenase activity in rat spleen and brain microsomal fractions is determined by the quantitation of CO formed from the degradation of methemalbumin, i.e. heme complexed with albumin | Rattus norvegicus Sprague-Dawley | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Rattus norvegicus |
heme oxygenase-2 | - |
Rattus norvegicus |
HO-1 | - |
Rattus norvegicus |
HO-2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |