Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane | IC50: 0.0015 mM | Homo sapiens | |
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane | IC50: 0.0008 mM | Rattus norvegicus | |
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane | IC50: 0.0026 mM | Rattus norvegicus | |
(2S,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane | IC50: 0.02 mM | Rattus norvegicus | |
(2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane | IC50: 0.012 mM | Rattus norvegicus | |
2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane | IC50: 0.004 mM | Rattus norvegicus | |
2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dithiolane | IC50: 0.0047 mM | Rattus norvegicus | |
azalanstat | IC50: 0.006 mM | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Homo sapiens | |
Fe2+ | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spleen | - |
Homo sapiens | - |
spleen | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + 2 NADPH + 2 H+ + 2 O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HO-1 | - |
Homo sapiens |
HO-1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens | |
heme | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0008 | - |
IC50: 0.0008 mM | Rattus norvegicus | (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane | |
0.0015 | - |
IC50: 0.0015 mM | Homo sapiens | (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane | |
0.0026 | - |
IC50: 0.0026 mM | Rattus norvegicus | (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane | |
0.004 | - |
IC50: 0.004 mM | Rattus norvegicus | 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane | |
0.0047 | - |
IC50: 0.0047 mM | Rattus norvegicus | 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dithiolane | |
0.006 | - |
IC50: 0.006 mM | Rattus norvegicus | azalanstat | |
0.012 | - |
IC50: 0.012 mM | Rattus norvegicus | (2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane | |
0.02 | - |
IC50: 0.02 mM | Rattus norvegicus | (2S,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane |