Application | Comment | Organism |
---|---|---|
medicine | allelic variants of CYP19A1 when present with a variant form of cytochrome P450 oxidoreductase POR may show different activities, and combined effects of natural variations in both the enzymes should be considered when genetic data are available | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R264C | with the wild-type cytochrome P450 oxidoreductase POR as a redox partner, polymorphism R264C shows only 15% of wild-type aromatase activity. With variant P284L-POR as a redox partner, R264C loses all activity but retains 6.7% of activity with P284T-POR | Homo sapiens |
R264H | with the wild-type cytochrome P450 oxidoreductase POR as a redox partner, polymorphism R264H shows 87% of wild-type aromatase activity but low activities with both the POR-P284L as well as the POR-P284T variants. The R264H variant has more than threefold higher activity compared to wild-type when the POR-Y607C variant is used as the redox partner | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11511 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins | - |
Homo sapiens | estrone + formate + 4 H2O + 3 oxidized flavoproteins | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP19A1 | - |
Homo sapiens |