Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Aptenodytes forsteri |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anastrozole | two-step binding mechanism, Kd value 0.0002 mM | Aptenodytes forsteri |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
androst-4-ene-3,17-dione | pH 7.4, temperature not specified in the publication | Aptenodytes forsteri |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aptenodytes forsteri | A0A087RFY9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
19-hydroxyandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein | - |
Aptenodytes forsteri | 19-oxo-androst-4-ene-3,17-dione + 2 H2O + an oxidized flavoprotein | - |
? | |
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins | - |
Aptenodytes forsteri | estrone + formate + 4 H2O + 3 oxidized flavoproteins | - |
? | |
additional information | androstenedione is the preferred substrate, the affinity of the intermediates progressively decrease with increased oxidation | Aptenodytes forsteri | ? | - |
- |
|
testosterone + 3 O2 + 3 reduced flavoproteins | - |
Aptenodytes forsteri | 17beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
androst-4-ene-3,17-dione | pH 7.4, temperature not specified in the publication | Aptenodytes forsteri |