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Literature summary for 1.14.11.65 extracted from

  • Kim, J.; Kim, K.; Eom, G.; Choe, N.; Kee, H.; Son, H.; Oh, S.; Kim, D.; Pak, J.; Baek, H.; Kook, H.; Hahn, Y.; Kook, H.; Chakravarti, D.; Seo, S.
    KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia (2012), Mol. Cell. Biol., 32, 2917-2933 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine KDM3B represses leukemia cell differentiation and is upregulated in blood cells from acute lymphoblastic leukemia-type leukemia patients Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7LBC6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Kdm3b
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function KDM3B contains a JmjC domain and is downregulated during differentiation through the recruitment of a corepressor complex. KDM3B displays histone H3K9-me1/2 demethylase activity and induces leukemogenic oncogene lmo2 expression via a synergistic interaction with CBP. KDM3B represses leukemia cell differentiation and is upregulated in blood cells from acute lymphoblastic leukemia-type leukemia patients Homo sapiens