Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9C0B1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | HCT-116 cells show high expression of both FTO and programmed cell death-ligand 1 (PD-L1) proteins. The knockdown of FTO decreases mRNA and protein levels of PD-L1 in HCT-116 cells. Upon depletion of FTO in HCT-116 cells in the presence of IFN-gamma to upregulate PD-L1 expression, PD-L1 expression is reduced in an IFN-gamma signaling-independent manner. PD-L1 mRNA is m6A-modified and FTO binds to the PD-L1 mRNA in HCT-116 cells | Homo sapiens |