Literature summary for 1.14.11.53 extracted from

Li, J.; Han, Y.; Zhang, H.; Qian, Z.; Jia, W.; Gao, Y.; Zheng, H.; Li, B.
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA (2019), Biochem. Biophys. Res. Commun., 512, 479-485 .

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Application

Application	Comment	Organism
medicine	FTO mRNA and protein levels are overexpressed in non-small cell lung cancer tissues and cell lines, associated with a reduced m6A content. FTO loss-of-function mutations reduce the proliferation rate of cancer cells. FTO knockdown also inhibits the colony formation ability of lung cancer cells. FTO knockdown reduces lung cancer cells growth in vivo. FTO decreases the m6A level and increases mRNA stability of ubiquitin-specific protease (USP7), which relies on the demethylase activity of FTO. USP7 mRNA level is overexpressed in human lung cancer tissues and USP7 expression was positively correlated with FTO mRNA level	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9C0B1	-	-

Synonyms

Synonyms	Comment	Organism
FTO	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	FTO loss-of-function mutations reduce the proliferation rate of cancer cells. FTO knockdown also inhibits the colony formation ability of lung cancer cells. FTO knockdown reduces lung cancer cells growth in vivo. FTO decreases the m6A level and increases mRNA stability of ubiquitin-specific protease (USP7), which relies on the demethylase activity of FTO	Homo sapiens

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Release 2023.1 (January 2023)