Cloned (Comment) | Organism |
---|---|
genomic structure of isozyme LH2, expression analysis of the 2 splicing variants of isozyme LH2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the long splicing variant of isozyme LH2 is the major ubiquitously-expressed form that is spliced into the short form, which is expressed together with the long form only in some tissues, e.g. kidney, spleen, liver, and placenta, alternative splicing can be regulated by both cell density and cycloheximide, regulation of LH2long transcript and of expression of both splicing variants in kidney via cycloheximide that suppress a factor taht inhibits exclusion of exon 13A thereby promoting expression of LH2short, and vice versa also via cycloheximide in fibroblasts, overview, perturbation of LH2 regulation can influence the stability of the extracellular matrix and contribute to connective tissue disorders | ? | - |
? | |
procollagen L-lysine + 2-oxoglutarate + O2 | Homo sapiens | some hydroxylated L-lysine residues are precursors for the cross-link formation essential for the tensile strength of collagen, the 2 splicing variants exhibit different specificity for hydroxylation of either telopeptide or helical collagen domain lysine residues, so that their relative expression level determines the type of cross-links formed and affecting collagen strength | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00469 | 2 splicing variants of isozyme LH2, termed LH2long and LH2short | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | expression only of LH2long | Homo sapiens | - |
cartilage | expression of LH2long and LH2short | Homo sapiens | - |
dura | expression only of LH2long | Homo sapiens | - |
fibroblast | of skin, expression only of LH2long | Homo sapiens | - |
HEK-293 cell | expression of LH2long and LH2short | Homo sapiens | - |
kidney | expression of LH2long and LH2short | Homo sapiens | - |
liver | expression of LH2long and LH2short | Homo sapiens | - |
lung | expression only of LH2long | Homo sapiens | - |
additional information | the long splicing variant of isozyme LH2 is the major ubiquitously-expressed form that is spliced into the short form, which is expressed together with the long form only in some tissues, e.g. kidney, cartilage, spleen, liver, and placenta, not in skin, lung, aorta, and dura | Homo sapiens | - |
placenta | expression of LH2long and LH2short | Homo sapiens | - |
skin | expression only of LH2long | Homo sapiens | - |
spleen | expression of LH2long and LH2short | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the long splicing variant of isozyme LH2 is the major ubiquitously-expressed form that is spliced into the short form, which is expressed together with the long form only in some tissues, e.g. kidney, spleen, liver, and placenta, alternative splicing can be regulated by both cell density and cycloheximide, regulation of LH2long transcript and of expression of both splicing variants in kidney via cycloheximide that suppress a factor taht inhibits exclusion of exon 13A thereby promoting expression of LH2short, and vice versa also via cycloheximide in fibroblasts, overview, perturbation of LH2 regulation can influence the stability of the extracellular matrix and contribute to connective tissue disorders | Homo sapiens | ? | - |
? | |
procollagen L-lysine + 2-oxoglutarate + O2 | - |
Homo sapiens | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
procollagen L-lysine + 2-oxoglutarate + O2 | some hydroxylated L-lysine residues are precursors for the cross-link formation essential for the tensile strength of collagen, the 2 splicing variants exhibit different specificity for hydroxylation of either telopeptide or helical collagen domain lysine residues, so that their relative expression level determines the type of cross-links formed and affecting collagen strength | Homo sapiens | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LH | - |
Homo sapiens |
lysyl hydroxylase | - |
Homo sapiens |