Application | Comment | Organism |
---|---|---|
medicine | deficiency in enzyme activity causes the Ehler-Danlos syndrome type 6 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in insect cells using a baculovirus vector | Homo sapiens |
expression in various human tissues | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
2-oxoglutarate | lysyl hydroxylases 1 and 3 | Homo sapiens | |
0.3 | - |
ascorbate | lysyl hydroxylase 3 | Homo sapiens | |
0.35 | - |
ascorbate | lysyl hydroxylase 1 | Homo sapiens | |
0.5 | - |
Ala-Arg-Gly-Ile-Lys-Gly-Ile-Arg-Gly-Phe-Ser-Gly | lysyl hydroxylase 1 | Homo sapiens | |
0.6 | - |
Ala-Arg-Gly-Ile-Lys-Gly-Ile-Arg-Gly-Phe-Ser-Gly | lysyl hydroxylase 3 | Homo sapiens | |
0.7 | - |
(Ile-Lys-Gly)3 | lysyl hydroxylase 1 | Homo sapiens | |
0.8 | - |
(Ile-Lys-Gly)3 | lysyl hydroxylase 3 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
82380 | - |
2 * 82380, calculation from amino acid sequence, recombinant enzyme: isoform 3 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen + 2-oxoglutarate + O2 | Homo sapiens | enzyme required during collagen biosynthesis | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60568 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | hydroxylation of lysyl residue in -X-Lys-Gly | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | existence of isoforms | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(Ile-Lys-Gly)3 + 2-oxoglutarate + O2 | - |
Homo sapiens | (Ile-5-hydroxylyseine-Gly)3 + succinate + CO2 | - |
? | |
2-oxoglutarate + O2 + ascorbate | - |
Homo sapiens | succinate + CO2 + dehydroascorbate + H2O | - |
? | |
Ala-Arg-Gly-Ile-Lys-Gly-Ile-Arg-Gly-Phe-Ser-Gly + 2-oxoglutarate + O2 | - |
Homo sapiens | Ala-Arg-Gly-Ile-5-hydroxylysine-Gly-Ile-Arg-Gly-Phe-Ser-Gly + succinate + CO2 | - |
? | |
collagen + 2-oxoglutarate + O2 | enzyme required during collagen biosynthesis | Homo sapiens | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
peptidyl-L-lysine + 2-oxoglutarate + O2 | synthetic peptides | Homo sapiens | peptidyl-5-hydroxy-L-lysine + succinate + CO2 | hydroxy-L-lysine | ? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 82380, calculation from amino acid sequence, recombinant enzyme: isoform 3 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
lysyl hydroxylase | lysyl hydroxylase 3 | Homo sapiens |