Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8BLR9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic fibroblast | - |
Mus musculus | - |
fibroblast | embryonic fibriblast | Mus musculus | - |
skeletal muscle | expresses 50fold higher levels of FIH than other tissues | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
asparaginyl hydroxylase | - |
Mus musculus |
FIH | - |
Mus musculus |
hypoxia-inducible factor 1-alpha inhibitor | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | FIH loss increases oxidative metabolism and also increases glycolytic capacity, this gives rise to an increase in oxygen consumption. The loss of FIH acts to accelerate the cellular metabolic response to hypoxia. FIH suppresses hypoxia-induced mitochondrial reactive oxygen species production and FIH loss accelerates the effects of hypoxic exposure on mitochondria | Mus musculus |
physiological function | the enzyme controls HIF transcriptional activity in an oxygen-dependent manner | Mus musculus |