Application | Comment | Organism |
---|---|---|
pharmacology | the prolyl 3-hydroxylase P3H2 is a novel targets for epigenetic silencing in breast cancer | Homo sapiens |
pharmacology | the prolyl 3-hydroxylase P3H3 is a novel targets for epigenetic silencing in breast cancer | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q32P28 | P3H2 | - |
Homo sapiens | Q8IVL6 | P3H3 | - |
Synonyms | Comment | Organism |
---|---|---|
Leprel1 | - |
Homo sapiens |
Leprel2 | - |
Homo sapiens |
P3H2 | - |
Homo sapiens |
P3H3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme expression of P3H2 and P3H3 is downregulated in breast cancer by abberrant CpG methylation in the 5'-regulatory sequences of each gene, methylation of P3H3 is not associated with higher tumour grade and Nottingham prognostic index | down |
Homo sapiens | the enzyme expression of P3H2 is downregulated in breast cancer by abberrant CpG methylation in the 5'-regulatory sequences of each gene, methylation of P3H2 is specific for breast cancer and does not occur in other cancer cell types, it is strongly associated with higher tumour grade and Nottingham prognostic index | down |
General Information | Comment | Organism |
---|---|---|
physiological function | P3H2 can function as a tumour suppressors in breast cancer | Homo sapiens |
physiological function | P3H3 can function as a tumour suppressors in breast cancer | Homo sapiens |