Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96SZ5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ADO | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ADO catalyzes conversion of N-terminal cysteine to cysteine sulfinic acid, reaction of EC 1.13.11.20, and is related to the plant cysteine oxidases that mediate responses to hypoxia by an identical post-translational modification. In human cells ADO regulates the RGS4/5 (regulator of G-protein signalling) N-degron substrates, modulates G-protein coupled Ca2+ signals and MAPK activity, and acts on N-terminal cysteine proteins including the angiogenic cytokine IL-32. Inactivation of ADO leads to constitutive upregulation of endogenous and transfected RGS4 and RGS5 proteins irrespective of oxygen levels | Homo sapiens |