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Literature summary for 1.11.1.27 extracted from

  • Chen, C.; Gong, L.; Liu, X.; Zhu, T.; Zhou, W.; Kong, L.; Luo, J.
    Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer (2021), Redox Biol., 46, 102130 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
withangulatin A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 glutathione + ROOH Homo sapiens
-
 glutathione disulfide + H2O + ROH
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P30041
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI-H1975 cell
-
 Homo sapiens
-
non-small cell lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 glutathione + ROOH
-
 Homo sapiens glutathione disulfide + H2O + ROH
-
 ?

Subunits

Subunits Comment Organism
? x * 25000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
GPX
-
 Homo sapiens
peroxiredoxin 6 bifunctional enzyme with glutathione peroxidase activity and Ca2+-independent phospholipase A2 activity Homo sapiens
Prdx6
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00118
-
 pH and temperature not specified in the publication Homo sapiens withangulatin A