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Literature summary for 1.11.1.26 extracted from

  • Rocha, L.S.; Silva, B.P.D.; Correia, T.M.L.; Silva, R.P.D.; Meireles, D.A.; Pereira, R.; Netto, L.E.S.; Meotti, F.C.; Queiroz, R.F.
    Peroxiredoxin AhpC1 protects Pseudomonas aeruginosa against the inflammatory oxidative burst and confers virulence (2021), Redox Biol., 46, 102075 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.11.1.26

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa A0A072ZH89
-
-
Pseudomonas aeruginosa UCBPP-PA14 A0A072ZH89
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap column chromatography, and Superdex 200 gel filtration Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H2O2 + H+
-
 Pseudomonas aeruginosa NAD+ + 2 H2O
-
 ?
NADH + H2O2 + H+
-
 Pseudomonas aeruginosa UCBPP-PA14 NAD+ + 2 H2O
-
 ?
NADH + urate hydroperoxide + H+
-
 Pseudomonas aeruginosa ?
-
 ?
NADH + urate hydroperoxide + H+
-
 Pseudomonas aeruginosa UCBPP-PA14 ?
-
 ?

Synonyms

Synonyms Comment Organism
AhpC1
-
 Pseudomonas aeruginosa
alkyl-hydroperoxide reductase C1
-
 Pseudomonas aeruginosa

General Information

General Information Comment Organism
malfunction enzyme deletion leads to a higher sensitivity to hypochlorous acid, hydrogen peroxide and urate hydroperoxide. The enzyme-deficient strain is more sensitive to the killing by isolated neutrophils and less virulent in a mice model of infection Pseudomonas aeruginosa
physiological function the enzyme is a relevant scavenger of oxidants generated during inflammatory oxidative burst and a mechanism of Pseudomonas aeruginosa escaping from killing Pseudomonas aeruginosa