Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P52209 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
acute myeloid leukemia cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
drug target | targeting 6-phosphogluconate dehydrogenase (6PGD) and NADPH production is sufficient to block growth of acute myeloid leukemia cell lines resistant to the chemotherapeutics daunorubicin and cytarabine. Stromal cell-mediated resistance to targeted inhibition of oncogenic FLT3 kinase activity by quizartinib is circumvented by 6PGD knockdown | Homo sapiens |
physiological function | acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming | Homo sapiens |