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Literature summary for 1.1.1.23 extracted from

  • Grubmeyer, C.; Teng, H.
    Mechanism of Salmonella typhimurium histidinol dehydrogenase: kinetic isotope effects and pH profiles (1999), Biochemistry, 38, 7355-7362.
    View publication on PubMed
Search for more literature for 1.1.1.23

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidinal + NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium reaction intermediate L-histidine + NADH + H+
-
 ir
L-histidinol + 2 NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 L-histidine + 2 NADH + 2 H+
-
 ir

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ fast reversible oxidation of L-histidanol, followed by slow irreversible hydride transfer from the intermediate L-histidinal Salmonella enterica subsp. enterica serovar Typhimurium
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidinal + NAD+ + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+
-
 ir
L-histidinal + NAD+ + H2O reaction intermediate Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+
-
 ir
L-histidinol + 2 NAD+ + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + 2 NADH + 2 H+
-
 ir

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium