Cloned (Comment) | Organism |
---|---|
gene UGDH, real-time quantitative PCR enzyme expression analysis | Homo sapiens |
gene UGDH, real-time quantitative PCR enzyme expression analysis | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | UGDH specific siRNAs markedly inhibits UGDH mRNA and protein expression, and leads to an obvious suppression of PGs synthesis in human articular chondrocytes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-glucose + 2 NAD+ + H2O | Homo sapiens | - |
UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? | |
UDP-alpha-D-glucose + 2 NAD+ + H2O | Rattus norvegicus | - |
UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? | |
UDP-alpha-D-glucose + 2 NAD+ + H2O | Rattus norvegicus Wistar | - |
UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60701 | - |
- |
Rattus norvegicus | O70199 | - |
- |
Rattus norvegicus Wistar | O70199 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Rattus norvegicus | - |
cartilage | specimens from the knee joints | Homo sapiens | - |
chondrocyte | articular | Homo sapiens | - |
chondrocyte | articular | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-glucose + 2 NAD+ + H2O | - |
Homo sapiens | UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? | |
UDP-alpha-D-glucose + 2 NAD+ + H2O | - |
Rattus norvegicus | UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? | |
UDP-alpha-D-glucose + 2 NAD+ + H2O | - |
Rattus norvegicus Wistar | UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucose dehydrogenase | - |
Homo sapiens |
UDP-glucose dehydrogenase | - |
Rattus norvegicus |
UGDH | - |
Homo sapiens |
UGDH | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | interleukin-1beta, IL-1beta, suppresses UGDH gene expression in human articular chondrocytes in the late phase, which also modulates gene expression of Sp1, Sp3 and c-Krox and increased both Sp3/Sp1 and c-Krox/Sp1 ratio. The inhibition of SAP/JNK and p38 MAPK pathways both result in an obvious attenuation of the IL-1beta-induced suppression on UGDH gene expression | down |
General Information | Comment | Organism |
---|---|---|
malfunction | UGDH protein level in rat osteoarthritis cartilage are much lower than the corresponding controls and negatively correlated to the degree of osteoarthritis | Rattus norvegicus |
malfunction | UGDH specific siRNAs markedly inhibits UGDH mRNA and protein expression, and leads to an obvious suppression of proteoglycans synthesis in human articular chondrocytes. UGDH protein level in human osteoarthritis cartilage are much lower than the corresponding controls and negatively correlated to the degree of osteoarthritis. Interleukin-1beta inhibits UGDH gene expression through modulating UGDH transregulators and the downstream signaling cascades, including the SAP/JNK and p38 MAPK pathways which might be involved in the proteoglycans loss of osteoarthritis cartilage and contribute to the osteoarthritis pathogenesis | Homo sapiens |
physiological function | UGDH is essential in the proteoglycan synthesis in articular chondrocytes, overview | Rattus norvegicus |
physiological function | UGDH is essential in the proteoglycan synthesis in articular chondrocytes, overview. UDP-glucuronic acid is a key precursor for the synthesis of the glycosaminoglycan chain in proteoglycans | Homo sapiens |