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Literature summary for 1.1.1.22 extracted from

  • Wen, Y.; Li, J.; Wang, L.; Tie, K.; Magdalou, J.; Chen, L.; Wang, H.
    UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis (2014), Arthritis Res. Ther., 16, 484-494.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene UGDH, real-time quantitative PCR enzyme expression analysis Homo sapiens
gene UGDH, real-time quantitative PCR enzyme expression analysis Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information UGDH specific siRNAs markedly inhibits UGDH mRNA and protein expression, and leads to an obvious suppression of PGs synthesis in human articular chondrocytes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucose + 2 NAD+ + H2O Homo sapiens
-
UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
?
UDP-alpha-D-glucose + 2 NAD+ + H2O Rattus norvegicus
-
UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
?
UDP-alpha-D-glucose + 2 NAD+ + H2O Rattus norvegicus Wistar
-
UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60701
-
-
Rattus norvegicus O70199
-
-
Rattus norvegicus Wistar O70199
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
Rattus norvegicus
-
cartilage specimens from the knee joints Homo sapiens
-
chondrocyte articular Homo sapiens
-
chondrocyte articular Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
Homo sapiens UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
?
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
Rattus norvegicus UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
?
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
Rattus norvegicus Wistar UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
?

Synonyms

Synonyms Comment Organism
UDP-glucose dehydrogenase
-
Homo sapiens
UDP-glucose dehydrogenase
-
Rattus norvegicus
UGDH
-
Homo sapiens
UGDH
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens interleukin-1beta, IL-1beta, suppresses UGDH gene expression in human articular chondrocytes in the late phase, which also modulates gene expression of Sp1, Sp3 and c-Krox and increased both Sp3/Sp1 and c-Krox/Sp1 ratio. The inhibition of SAP/JNK and p38 MAPK pathways both result in an obvious attenuation of the IL-1beta-induced suppression on UGDH gene expression down

General Information

General Information Comment Organism
malfunction UGDH protein level in rat osteoarthritis cartilage are much lower than the corresponding controls and negatively correlated to the degree of osteoarthritis Rattus norvegicus
malfunction UGDH specific siRNAs markedly inhibits UGDH mRNA and protein expression, and leads to an obvious suppression of proteoglycans synthesis in human articular chondrocytes. UGDH protein level in human osteoarthritis cartilage are much lower than the corresponding controls and negatively correlated to the degree of osteoarthritis. Interleukin-1beta inhibits UGDH gene expression through modulating UGDH transregulators and the downstream signaling cascades, including the SAP/JNK and p38 MAPK pathways which might be involved in the proteoglycans loss of osteoarthritis cartilage and contribute to the osteoarthritis pathogenesis Homo sapiens
physiological function UGDH is essential in the proteoglycan synthesis in articular chondrocytes, overview Rattus norvegicus
physiological function UGDH is essential in the proteoglycan synthesis in articular chondrocytes, overview. UDP-glucuronic acid is a key precursor for the synthesis of the glycosaminoglycan chain in proteoglycans Homo sapiens