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Literature summary for 1.1.1.205 extracted from

  • Buey, R.M.; Fernandez-Justel, D.; Marcos-Alcalde, I.; Winter, G.; Gomez-Puertas, P.; de Pereda, J.M.; Luis Revuelta, J.
    A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases (2017), Sci. Rep., 7, 2648 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.205

Activating Compound

Activating Compound Comment Organism Structure
ATP
-
 Eremothecium gossypii

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with ATP, vapor diffusion method, using 0.02 M D-glucose, 0.02 M D-mannose, 0.02 M D-galactose, 0.02 M L-sucrose, 0.02 M D-xylose,0.02 M N-acetyl-D-glucosamine, 0.05 M imidazole, 0.05 M MES, pH 6.5, 20% (w/v) glycerol, 20% (w/v) PEG-4000. Enzyme in complex with ATP/GDP, vapor diffusion method, using 0.1 M lithium acetate, 0.1 M Bis-Tris pH 6.0, 20% (w/v) Sokolan-CP42 Eremothecium gossypii

Inhibitors

Inhibitors Comment Organism Structure
GDP
-
 Eremothecium gossypii
GTP
-
 Eremothecium gossypii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Eremothecium gossypii
-
 XMP + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Eremothecium gossypii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Eremothecium gossypii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + NAD+ + H2O
-
 Eremothecium gossypii XMP + NADH + H+
-
 ?

Subunits

Subunits Comment Organism
homotetramer small angle X-ray scattering Eremothecium gossypii

Synonyms

Synonyms Comment Organism
IMPDH
-
 Eremothecium gossypii
inosine-5'-monophosphate dehydrogenase
-
 Eremothecium gossypii

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Eremothecium gossypii