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Literature summary for 1.1.1.205 extracted from

  • Fernandez-Justel, D.; Pelaez, R.; Revuelta, J.L.; Buey, R.M.
    The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates (2019), J. Biol. Chem., 294, 14768-14775 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Ap4A slight activation Eremothecium gossypii
Ap5A slight activation Eremothecium gossypii
Ap6A slight activation Eremothecium gossypii
ATP slight activation Eremothecium gossypii

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Eremothecium gossypii

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with Ap5G and GDP, vapor diffusion method, using 20% (w/v) PEG-6000, 0.1 M sodium acetate, pH 5.0, 0.2 M sodium chloride Eremothecium gossypii

Inhibitors

Inhibitors Comment Organism Structure
GDP
-
Eremothecium gossypii

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 1 mM used in assay conditions Eremothecium gossypii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Eremothecium gossypii
-
XMP + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Eremothecium gossypii Q756Z6
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography and Sephacryl S-300 gel filtration Eremothecium gossypii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + NAD+ + H2O
-
Eremothecium gossypii XMP + NADH + H+
-
?

Subunits

Subunits Comment Organism
tetramer small angle X-ray scattering Eremothecium gossypii

Synonyms

Synonyms Comment Organism
IMPDH
-
Eremothecium gossypii

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Eremothecium gossypii