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Literature summary for 1.1.1.205 extracted from

  • Kofuji, S.; Sasaki, A.T.
    GTP metabolic reprogramming by IMPDH2 unlocking cancer cells fuelling mechanism (2020), J. Biochem., 168, 319-328 .
    View publication on PubMed
Search for more literature for 1.1.1.205

Inhibitors

Inhibitors Comment Organism Structure
GTP
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Homo sapiens
-
 XMP + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P12268
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte highest expression Homo sapiens
-
esophagus high expression Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
LN-229 cell
-
 Homo sapiens
-
lymph node high expression Homo sapiens
-
retina high expression Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + NAD+ + H2O
-
 Homo sapiens XMP + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
IMPDH2
-
 Homo sapiens
inosine monophosphate dehydrogenase-2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform IMPDH2 expression is increased in glioblastoma up

General Information

General Information Comment Organism
malfunction enzyme dysfunction leads to retinitis pigmentosa Homo sapiens
metabolism rate-limiting enzyme for guanosine triphosphate synthesis Homo sapiens
physiological function increased isoform IMPDH2 enhances RNA polymerase I and III transcription directly linking GTP metabolism to both anabolic capacity as well as nucleolar enlargement historically observed as associated with cancer. Isoform IMPDH2 has the essential function in embryogenesis that cannot be compensated by isoform IMPDH1 Homo sapiens