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Literature summary for 1.1.1.205 extracted from

  • Sahu, N.U.; Purushothaman, G.; Thiruvenkatam, V.; Kharkar, P.S.
    Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors (2019), Drug Dev. Res., 80, 125-132 .
    View publication on PubMed
Search for more literature for 1.1.1.205

Inhibitors

Inhibitors Comment Organism Structure
(1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate
-
 Helicobacter pylori
(1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate
-
 Homo sapiens
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole
-
 Helicobacter pylori
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole 0.1% inhibition at 0.01 mM Homo sapiens
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole
-
 Helicobacter pylori
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole 0.1% inhibition at 0.01 mM Homo sapiens
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole
-
 Helicobacter pylori
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole 0.1% inhibition at 0.01 mM Homo sapiens
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole
-
 Helicobacter pylori
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole 0.1% inhibition at 0.01 mM Homo sapiens
1-[(3-methoxyphenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole
-
 Helicobacter pylori
1-[(3-methoxyphenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole 30.66% inhibition at 0.01 mM Homo sapiens
1-[(3-methoxyphenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole
-
 Helicobacter pylori
1-[(3-methoxyphenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole 24.94% inhibition at 0.01 mM Homo sapiens
2-([2-[2-(furan-2-yl)phenyl]-4-oxo-4H-1-benzopyran-3-yl]oxy)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
-
 Helicobacter pylori
2-([2-[2-(furan-2-yl)phenyl]-4-oxo-4H-1-benzopyran-3-yl]oxy)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide 0.1% inhibition at 0.01 mM Homo sapiens
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
-
 Helicobacter pylori
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
-
 Homo sapiens
2-[4-([1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole
-
 Helicobacter pylori
2-[4-([1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole 0.1% inhibition at 0.01 mM Homo sapiens
2-[4-([1-[(3-chlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole
-
 Helicobacter pylori
2-[4-([1-[(3-chlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole 0.1% inhibition at 0.01 mM Homo sapiens
2-[4-([1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole
-
 Helicobacter pylori
2-[4-([1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole 0.1% inhibition at 0.01 mM Homo sapiens
2-[[2-(2-chlorophenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
-
 Helicobacter pylori
2-[[2-(2-chlorophenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide 0.1% inhibition at 0.01 mM Homo sapiens
2-[[2-(3,4-dimethoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
-
 Helicobacter pylori
2-[[2-(3,4-dimethoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide 34.45% inhibition at 0.01 mM Homo sapiens
2-[[2-(3,4-dimethoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(naphthalen-1-yl)acetamide
-
 Helicobacter pylori
2-[[2-(3,4-dimethoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(naphthalen-1-yl)acetamide 0.1% inhibition at 0.01 mM Homo sapiens
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
-
 Helicobacter pylori
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide 56.81% inhibition at 0.01 mM Homo sapiens
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(naphthalen-1-yl)acetamide
-
 Helicobacter pylori
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(naphthalen-1-yl)acetamide 2.1% inhibition at 0.01 mM Homo sapiens
2-[[2-(4-methylphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
-
 Helicobacter pylori
2-[[2-(4-methylphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide 0.1% inhibition at 0.01 mM Homo sapiens
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
-
 Helicobacter pylori
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
-
 Homo sapiens
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
-
 Helicobacter pylori
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
-
 Homo sapiens
N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-([4-oxo-2-[2-(thiophen-2-yl)phenyl]-4H-1-benzopyran-3-yl]oxy)acetamide
-
 Helicobacter pylori
N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-([4-oxo-2-[2-(thiophen-2-yl)phenyl]-4H-1-benzopyran-3-yl]oxy)acetamide 0.1% inhibition at 0.01 mM Homo sapiens
N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-[[4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy]acetamide
-
 Helicobacter pylori
N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-[[4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy]acetamide 0.1% inhibition at 0.01 mM Homo sapiens
N-(4-bromophenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]acetamide
-
 Helicobacter pylori
N-(4-bromophenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]acetamide 0.1% inhibition at 0.01 mM Homo sapiens
N-(4-bromophenyl)-2-[[2-(4-methylphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]acetamide
-
 Helicobacter pylori
N-(4-bromophenyl)-2-[[2-(4-methylphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]acetamide 0.1% inhibition at 0.01 mM Homo sapiens
N-(4-chlorophenyl)-2-phenoxypropanamide
-
 Helicobacter pylori
N-(4-chlorophenyl)-2-phenoxypropanamide
-
 Homo sapiens
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
-
 Helicobacter pylori
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
-
 Homo sapiens
N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide
-
 Helicobacter pylori
N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide
-
 Homo sapiens
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
-
 Helicobacter pylori
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
-
 Homo sapiens
N-(naphthalen-1-yl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-3-yl)oxy]acetamide
-
 Helicobacter pylori
N-(naphthalen-1-yl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-3-yl)oxy]acetamide 0.1% inhibition at 0.01 mM Homo sapiens
N-(naphthalen-1-yl)-2-[[4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy]acetamide
-
 Helicobacter pylori
N-(naphthalen-1-yl)-2-[[4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy]acetamide 16.54% inhibition at 0.01 mM Homo sapiens
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide
-
 Helicobacter pylori
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide C91, 0.197% inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Helicobacter pylori
-
 XMP + NADH + H+
-
 ?
IMP + NAD+ + H2O Homo sapiens
-
 XMP + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Homo sapiens P12268
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + NAD+ + H2O
-
 Helicobacter pylori XMP + NADH + H+
-
 ?
IMP + NAD+ + H2O
-
 Homo sapiens XMP + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
IMPDH
-
 Helicobacter pylori
IMPDH2
-
 Homo sapiens
inosine 5'-monophosphate dehydrogenase
-
 Helicobacter pylori
inosine 5'-monophosphate dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Helicobacter pylori
NAD+
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00127
-
 at pH 7.6 and 37°C Helicobacter pylori 1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole
0.00188
-
 at pH 7.6 and 37°C Helicobacter pylori 2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
0.0021
-
 at pH 7.6 and 37°C Helicobacter pylori 1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole
0.00406
-
 at pH 7.6 and 37°C Helicobacter pylori 2-[4-([1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole