Literature summary for 1.1.1.205 extracted from

Andashti, B.; Yazdanparast, R.; Motahar, M.; Barzegari, E.; Galehdari, H.
Terminal peptide extensions augment the retinal IMPDH1 catalytic activity and attenuate the ATP-induced fibrillation events (2021), Cell Biochem. Biophys., 79, 221-229 .

Search for more literature for 1.1.1.205

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
GTP	-	Mus musculus
Mycophenolic acid	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
IMP + NAD+ + H2O	Mus musculus	-	XMP + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P50096	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA agarose resin column chromatography	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
retina	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
IMP + NAD+ + H2O	-	Mus musculus	XMP + NADH + H+	-	?

Subunits

Subunits	Comment	Organism
tetramer or octamer	-	Mus musculus

Synonyms

Synonyms	Comment	Organism
IMPDH1	-	Mus musculus
inosine monophosphate dehydrogenase-1	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	defects in inosine monophosphate dehydrogenase-1 lead to insufficient biosyntheses of purine nucleotides and are believed to cause retinitis pigmentosa in eyes	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)