Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2R,3R,5S)-2,3,5-trihydroxy-5-(propylcarbamoyl)cyclohexyl (4E)-6-[4-(acetyloxy)-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate | - |
Homo sapiens | |
(1S,3R,4S,5R)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid | - |
Homo sapiens | |
(2-methoxy-4-nitrophenyl)methylene diacetate | - |
Homo sapiens | |
(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-enal | - |
Homo sapiens | |
(2E)-4-[4-(acetyloxy)-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-2-methylbut-2-enoic acid | - |
Homo sapiens | |
(2E)-4-{6-methoxy-7-methyl-3-oxo-4-[2-(trimethylsilyl)ethoxy]-1,3-dihydro-2-benzofuran-5-yl}-2-methylbut-2-enal | - |
Homo sapiens | |
(2E)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-phenylprop-2-enamide | - |
Homo sapiens | |
(2E)-N-hydroxy-3-[3-({[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoyl}amino)phenyl]prop-2-enamide | - |
Homo sapiens | |
(2E)-N-hydroxy-3-[4-({[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoyl}amino)phenyl]prop-2-enamide | - |
Homo sapiens | |
(3aR,4R,6S,7aR)-6-hydroxy-2,2-dimethyl-6-(propylcarbamoyl)hexahydro-2H-1,3-benzodioxol-4-yl (4E)-6-[4-(acetyloxy)-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate | - |
Homo sapiens | |
(3aR,4R,7S,8aR)-7-hydroxy-2,2-dimethyltetrahydro-2H-4,7-methano[1,3]dioxolo[4,5-c]oxepin-6(4H)-one | - |
Homo sapiens | |
(3aR,5R,7R,7aS)-5,7-dihydroxy-2,2-dimethyl-N-propylhexahydro-2H-1,3-benzodioxole-5-carboxamide | - |
Homo sapiens | |
(3S)-oxolan-3-yl {[3-({[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoyl}amino)phenyl]methyl}carbamate | - |
Homo sapiens | |
(3S,4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3,4-dimethylhex-4-enoic acid | - |
Homo sapiens | |
(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde | - |
Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-(1H-1,2,4-triazol-5-yl)hex-4-enamide | - |
Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-{[(1-nitro-4a,9a-dihydroacridin-9-yl)amino]methyl}hex-4-enamide | - |
Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-{[(4-nitro-9-oxo-4a,9,9a,10-tetrahydroacridin-1-yl)amino]methyl}hex-4-enamide | - |
Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enal | - |
Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | - |
Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid | - |
Homo sapiens | |
(4E)-N-hydroxy-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | - |
Homo sapiens | |
(E)-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-1-(thiophen-2-yl)methanimine | - |
Homo sapiens | |
({hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl}methyl)phosphonic acid | - |
Homo sapiens | |
1-[3,4-bis(benzyloxy)-5-oxo-2,5-dihydrofuran-2-yl]ethane-1,2-diyl diacetate | - |
Homo sapiens | |
1-{5-O-[hydroxy({hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl}methyl)phosphoryl]-beta-D-ribofuranosyl}-1H-benzimidazol-4-amine | - |
Homo sapiens | |
2,2,2-trichloroethyl (1-oxo-1,3-dihydro-2-benzofuran-5-yl)carbamate | - |
Homo sapiens | |
2-(methyl{2-[(2lambda~5~-triaza-1,2-dien-2-yl)acetyl]phenyl}amino)-2-oxoethyl acetate | - |
Homo sapiens | |
2-anilino-5-fluorobenzene-1,4-dicarboxylic acid | - |
Homo sapiens | |
2-ethyl-5'-O-[hydroxy({hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl}methyl)phosphoryl]adenosine | - |
Homo sapiens | |
2-fluoro-9-oxo-4a,9,9a,10-tetrahydroacridine-3-carboxylic acid | - |
Homo sapiens | |
2-methoxy-1-methyl-4-nitrobenzene | - |
Homo sapiens | |
2-methoxy-4-nitrobenzaldehyde | - |
Homo sapiens | |
2-[(2-{2-[3-methoxy-4-(1,3-oxazol-5-yl)anilino]-1,3-oxazol-5-yl}phenyl)(methyl)amino]-2-oxoethyl acetate | - |
Homo sapiens | |
2-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]propan-2-amine | - |
Homo sapiens | |
3-methoxy-4-(1,3-oxazol-5-yl)aniline | - |
Homo sapiens | |
4-nitro-1-beta-D-ribofuranosyl-1H-benzimidazole | - |
Homo sapiens | |
5'-amino-5'-deoxyadenosine | - |
Homo sapiens | |
5'-deoxy-5'-[(3-{[(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoyl]amino}-2-oxopropyl)amino]adenosine | - |
Homo sapiens | |
5'-O-({[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]sulfamoyl}methanesulfonyl)adenosine | - |
Homo sapiens | |
5'-O-[hydroxy({hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl}methyl)phosphoryl]adenosine | - |
Homo sapiens | |
5-(2-methoxy-4-nitrophenyl)-1,3-oxazole | - |
Homo sapiens | |
5-(4-isothiocyanato-2-methoxyphenyl)-1,3-oxazole | - |
Homo sapiens | |
5-aminoisobenzofuran-1(3H)-one | - |
Homo sapiens | |
6-(4-ethylpiperazin-1-yl)pyridine-3-carbonitrile | - |
Homo sapiens | |
6-{(2E)-4-[4-({[(2S,5R)-5-(6-amino-7,8-dihydro-9H-purin-9-yl)oxolan-2-yl]methoxy}methyl)-1H-1,2,3-triazol-1-yl]-3-methylbut-2-en-1-yl}-7-hydroxy-5-methoxy-4-methyl-2-benzofuran-1(3H)-one | - |
Homo sapiens | |
7-hydroxy-5-methoxy-4-methyl-6-[(2E)-3-methyl-4-(2lambda~5~-triaza-1,2-dien-2-yl)but-2-en-1-yl]-2-benzofuran-1(3H)-one | - |
Homo sapiens | |
7-hydroxy-5-methoxy-4-methyl-6-{(2E)-3-methyl-6-[(2R)-oxiran-2-yl]-6-oxohex-2-en-1-yl}-2-benzofuran-1(3H)-one | - |
Homo sapiens | |
7-hydroxy-5-methoxy-4-methyl-6-{(2E)-3-methyl-6-[(2S)-oxiran-2-yl]-6-oxohex-2-en-1-yl}-2-benzofuran-1(3H)-one | - |
Homo sapiens | |
7-hydroxy-6-[(2E)-6-hydroxy-3-methylocta-2,7-dien-1-yl]-5-methoxy-4-methyl-2-benzofuran-1(3H)-one | - |
Homo sapiens | |
8-methoxy-8-oxooctanoic acid | - |
Homo sapiens | |
dimethyl 1-{(2Z)-2-[3,4-bis(benzyloxy)-5-oxofuran-2(5H)-ylidene]ethyl}-4,5-dihydro-1H-imidazole-4,5-dicarboxylate | - |
Homo sapiens | |
dimethyl 2-amino-5-fluorobenzene-1,4-dicarboxylate | - |
Homo sapiens | |
dimethyl 2-fluorobenzene-1,4-dicarboxylate | - |
Homo sapiens | |
dimethyl 4,5-dihydro-1H-imidazole-4,5-dicarboxylate | - |
Homo sapiens | |
ethyl (2E)-3-[3-methoxy-4-(1,3-oxazol-5-yl)anilino]-3-phenylprop-2-enoate | - |
Homo sapiens | |
ethyl (2E)-3-[4-({[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoyl}amino)phenyl]prop-2-enoate | - |
Homo sapiens | |
ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoyl carbonate | - |
Homo sapiens | |
methyl N-[(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoyl]alaninate | - |
Homo sapiens | |
mizoribine | - |
Homo sapiens | |
additional information | inhibitor synthesis, analysis and comparison of potencies against isozymes IMPDH1 and IMPDH2, overview; inhibitor synthesis, analysis and comparison of potencies against isozymes IMPDH1 and IMPDH2, overview | Homo sapiens | |
mycophenolate | - |
Homo sapiens | |
mycophenolate mofetil | - |
Homo sapiens | |
Mycophenolic acid | - |
Homo sapiens | |
N-(1,4-dinitroacridin-9-yl)methanediamine | - |
Homo sapiens | |
N-(1-nitroacridin-9-yl)methanediamine | - |
Homo sapiens | |
N-(2-{2-[3-methoxy-4-(1,3-oxazol-5-yl)anilino]-1,3-oxazol-5-yl}phenyl)-N-methyl-2-(morpholin-4-yl)acetamide | - |
Homo sapiens | |
N-methyl-N'-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)urea | - |
Homo sapiens | |
N-[(4-fluorophenyl)(1-methyl-1H-imidazol-2-yl)methyl]-2-methyl-3-(1,2,4-thiadiazol-5-yl)-1H-indole-6-carboxamide | - |
Homo sapiens | |
N-[(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoyl]alanine | - |
Homo sapiens | |
N-{2-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]propan-2-yl}-2-fluoro-9-oxo-4a,9,9a,10-tetrahydroacridine-3-carboxamide | - |
Homo sapiens | |
N1-methyl-N~2~-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethanediamide | - |
Homo sapiens | |
N~1~-hydroxy-N~8~-phenyloctanediamide | - |
Homo sapiens | |
N~1~-hydroxy-N~8~-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]octanediamide | - |
Homo sapiens | |
oxolan-3-yl {[3-({[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoyl}amino)phenyl]methyl}carbamate | - |
Homo sapiens | |
ribavirin | 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, a prodrug of corresponding 5-monophosphate, which as a competitive inhibitor interacts with the IMP domain of IMPDH; 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, a prodrug of corresponding 5-monophosphate, which as a competitive inhibitor interacts with the IMP domain of IMPDH | Homo sapiens | |
S-[(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-en-1-yl] ethanethioate | - |
Homo sapiens | |
tiazofurin | - |
Homo sapiens | |
[(2S,5R)-5-(6-amino-7,8-dihydro-9H-purin-9-yl)oxolan-2-yl]methyl cyanate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Homo sapiens | - |
XMP + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P12268 | IMPDH2 | - |
Homo sapiens | P20839 | IMPDH1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | - |
Homo sapiens | XMP + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPDH1 | - |
Homo sapiens |
IMPDH2 | - |
Homo sapiens |
IMPDHI | - |
Homo sapiens |
IMPDHII | - |
Homo sapiens |
inosine 5'-monophosphate dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |