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Literature summary for 1.1.1.205 extracted from

  • Beringer, A.; Citterio-Quentin, A.; Otero, R.O.; Gustin, C.; Clarke, R.; Salvi, J.P.; Boulieu, R.
    Determination of inosine 5-monophosphate dehydrogenase activity in red blood cells of thiopurine-treated patients using HPLC (2017), J. Chromatogr. B, 1044-1045, 194-199.
    View publication on PubMed

Application

Application Comment Organism
diagnostics IMPDH activity is measured in adults without thiopurine treatment as well as in adult and paediatric patients treated with thiopurines. A wide interindividual variability in IMPDH activity in erythrocytes is observed. No difference in IMPDH activity is found between untreated subjects and adult and paediatric patients on thiopurine therapy. The method described is useful in the determination of IMPDH phenotype from patients on thiopurine therapy and in the investigation of the potential relationship between IMPDH activity in erythrocytes and the occurrence of adverse events and drug response variability Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Homo sapiens
-
XMP + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P12268 IMPDH2
-
Homo sapiens P20839 IMPDH1
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte from healthy adults and paediatric patients on thiopurine therapy Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + beta-NAD+ + H2O
-
Homo sapiens XMP + beta-NADH + H+
-
?
IMP + NAD+ + H2O
-
Homo sapiens XMP + NADH + H+
-
?
additional information assay method optimization. XMP detection and quantification by anion exchange chromatography Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
IMPDH1
-
Homo sapiens
IMPDH2
-
Homo sapiens
inosine 5-monophosphate dehydrogenase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
beta-NAD+
-
Homo sapiens