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Literature summary for 1.1.1.205 extracted from
- A putative role for inosine 5 monophosphate dehydrogenase (IMPDH) in Leishmania amazonensis programmed cell death (2015), Exp. Parasitol., 149, 32-38.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition by tiazofurin and benzamide | Leishmania amazonensis | |
| Mycophenolic acid | - |
Leishmania amazonensis |  |
| ribavirin | - |
Leishmania amazonensis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| IMP + NAD+ + H2O | Leishmania amazonensis | - |
XMP + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania amazonensis | Q2TUW2 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| promastigote | - |
Leishmania amazonensis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| IMP + NAD+ + H2O | - |
Leishmania amazonensis | XMP + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IMPDH | - |
Leishmania amazonensis |
| inosine 5' monophosphate dehydrogenase | - |
Leishmania amazonensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Leishmania amazonensis | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Leishmania amazonensis | downregulation of impdh expression under heat shock treatment | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | IMPDH inhibitors ribavirin and mycophenolic acid prevents cell growth and generates an apoptosis-like phenotype in sub-populations of L.eishmania amazonensis promastigotes. A subpopulation of parasites undergoes apoptosislike cell death in the nutrient poor environment of the vector gut | Leishmania amazonensis |
| metabolism | IMPDH is a key enzyme in the purine nucleotide pathway | Leishmania amazonensis |
| physiological function | a small percentage of Leishmania amazonensis undergoes programmed cell death (PCD) under heat shock, imitating host infection reaction, involving the enzyme IMPDH of the purine metabolism. Enzyme IMPDH is a key enzyme in the purine nucleotide pathway, and is related to cell growth and apoptosis | Leishmania amazonensis |
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Release 2023.1 (January 2023)
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