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Literature summary for 1.1.1.192 extracted from

  • Van Ophem, P.W.; Van Beeumen, J.; Duine, J.A.
    NAD-linked, factor-dependent formaldehyde dehydrogenase or trimeric, zinc-containing, long-chain alcohol dehydrogenase from Amycolatopsis methanolica (1992), Eur. J. Biochem., 206, 511-518.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Amycolatopsis methanolica
CuCl2
-
Amycolatopsis methanolica
HgCl2
-
Amycolatopsis methanolica
KCN
-
Amycolatopsis methanolica
additional information inhibition differs for ethanol and formaldehyde as substrates Amycolatopsis methanolica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2
-
1-Octanol
-
Amycolatopsis methanolica
1.7
-
12-Hydroxydodecanoic acid
-
Amycolatopsis methanolica
3.4
-
1-Hexanol
-
Amycolatopsis methanolica
26.5
-
1-Pentanol
-
Amycolatopsis methanolica
84
-
1-butanol
-
Amycolatopsis methanolica
324
-
1-propanol
-
Amycolatopsis methanolica
343
-
ethanol
-
Amycolatopsis methanolica

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc 6.1 atoms/enzyme molecule Amycolatopsis methanolica

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
3 * 40000, SDS-PAGE Amycolatopsis methanolica
117000 120000 PAGE, gel filtration Amycolatopsis methanolica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
long-chain alcohol + NAD+ + H2O Amycolatopsis methanolica enzyme also uses formaldehyde and short chain aliphatic alcohols long-chain carboxylate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Amycolatopsis methanolica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-octanol + 2 NAD+ + H2O
-
Amycolatopsis methanolica octanoic acid + 2 NADH + 2 H+
-
r
12-hydroxydodecanoic acid + NAD+ + H2O
-
Amycolatopsis methanolica ? + NADH
-
?
ethanol + NAD+ + H2O
-
Amycolatopsis methanolica ethanal + NADH
-
?
long-chain alcohol + NAD+ + H2O enzyme also uses formaldehyde and short chain aliphatic alcohols Amycolatopsis methanolica long-chain carboxylate + NADH
-
?
n-butanol + NAD+ + H2O
-
Amycolatopsis methanolica n-butanal + NADH
-
?
n-hexanol + NAD+ + H2O
-
Amycolatopsis methanolica n-hexanal + NADH
-
?
n-pentanol + NAD+ + H2O
-
Amycolatopsis methanolica n-pentanal + NADH
-
?
n-propanol + NAD+ + H2O
-
Amycolatopsis methanolica n-propanal + NADH
-
?

Subunits

Subunits Comment Organism
More N-terminal sequence Amycolatopsis methanolica
trimer 3 * 40000, SDS-PAGE Amycolatopsis methanolica