Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + acetodethio-CoA + HCO3-
?
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
ATP + biotin + HCO3-
ADP + ? + phosphate
-
free biotin can be used as carboxyl acceptor with low activity
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
ATP + propionyl-CoA + HCO3-
ADP + methylmalonyl-CoA + phosphate
-
-
-
-
r
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
dATP + acetyl-CoA + HCO3-
dADP + phosphate + malonyl-CoA
-
-
-
-
?
GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
n-butyryl-CoA + HCO3-
?
4.6% activity compared to acetyl-CoA or propionyl-CoA
-
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
additional information
?
-
ATP + acetyl-CoA + HCO3-
?
-
key enzyme of 3-hydroxypropionate cycle
-
-
?
ATP + acetyl-CoA + HCO3-
?
n-butyryl-CoA (0.5 mM) is carboxylated at 4.6% compared to carboxylation of acetyl-CoA or propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA, which is used as the substrate in the biosynthesis of a variety of polyketide derivatives, including fatty acids, flavonoids, and stilbenoids. In addition malonyl-CoA is used as the substrate for the malonation of a variety of plant phytochemicals
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
first committed step in biosynthesis of fatty acids, providing the essential substrate for fatty acid synthetase
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
catalyzes the first committed step in the synthesis of fatty acids
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
key enzyme of de nove fatty acid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA which is required for plastid localized fatty acid biosynthesis and for a variety of pathways in the cytoplasm including flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
?
-
key role in lipid metabolism
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
regulation of isozyme expression and activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
hormonal, nutrient, and tissue-specific regulation of ACC genes, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme influences the fatty acid oxidation, body weight, and body fat levels, isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
biological function, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
biological function, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological role, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by pH, redox, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
r
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme is essential for viability
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme activity is limiting for lipid synthesis in tubers, biosynthetic pathway and regulatory aspects, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
r
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme activity is involved in biosynthesis of fatty acids as well as polyketids, which are precursors of pharmaceutically important antibiotics, anticancer agents and other drugs
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
wild-type enzyme, transcarboxylation between biotin and acetyl-CoA is catalyzed by the core catalytic beta-subunit
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
first committed step of fatty acid synthesis, physiological role, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
the enzyme catalyzes the first step in fatty acid bioynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
the bifunctional enzyme also catalyzes the carboxylation of propionyl-CoA. Vmax/Km for carboxylation of propanoyl-CoA is 1.6fold higher than Vmax/Km for carboxylation of acetyl-CoA. Quite specific for ATP. No activity with ADP, AMP, GTP, CTP, UTP, or dTTP (0.2 mM)
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
ACC catalyzes the first committed step in the synthesis of long-chain fatty acids
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
r
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
absolute specificity for acetyl-CoA
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
r
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10 -
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
ACC plays an important role in energy balance by controlling malonyl-CoA synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Pigeon
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
first enzyme in fatty acid biosynthesis, regulated by AMP-activated protein kinase, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
Sulfuracidifex metallicus Kra23 / DSM 6482
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
ATP in form of MgATP2-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
ATP in form of MgATP2-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
ATP in form of MgATP2-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
-
-
-
?
ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
-
ATP in form of MgATP2-
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
-
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
no activity
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
15% of the activity relative to acetyl-CoA
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
60% of the activity relative to acetyl-CoA
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
-
-
-
r
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
-
no activity
-
-
?
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
-
-
-
-
?
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
-
-
-
-
?
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
-
wild-type enzyme
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
10% of the activity relative to acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
no activity
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
acetyl-CoA carboxylase and propionyl-CoA carboxylase are different enzymes
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
no activity
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
second activity of the protein representing EC 6.4.1.3
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
second activity of the protein representing EC 6.4.1.3
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
60% of the activity relative to acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
maximal rate is 20% of that for acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
maximal rate is 20% of that for acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
13% of the activity relative to acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
-
45% of the activity compared to acetyl-CoA
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
-
highly preferred substrate
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
-
participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
-
wild-type and mutant I420D enzyme
-
-
?
GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
10% of the activity obtained with ATP
-
?
GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
10% of the activity obtained with ATP
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
40% of the activity obtained with ATP
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
40% of the activity obtained with ATP
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
-
at 2.5% of the activity relative to ATP
-
-
?
additional information
?
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
-
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
?
additional information
?
-
ACCase 1 is essential for correct plant development
-
-
?
additional information
?
-
-
acetyl-CoA carboxylase is a multifunctional biotin-dependent enzyme that catalyzes the first committed and regulated step in fatty acid biosynthesis in bacteria via a two-step reaction. Biotin carboxylase, EC 6.3.4.14, catalyzes the first half-reaction, which is an ATP-dependent carboxylation of biotin to form carboxybiotin. The second half-reaction is catalyzed by carboxyltransferase, EC 6.4.1.2, which transfers the carboxyl group from carboxybiotin to acetyl-CoA to generate malonyl-CoA
-
-
?
additional information
?
-
-
the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity
-
-
?
additional information
?
-
-
regulation of ACC is necessary for maintaining the energy balance
-
-
?
additional information
?
-
-
the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
-
-
?
additional information
?
-
-
isozymes ACC1 and ACC2 play roles in lipid metabolism in adipose tissue, overview
-
-
?
additional information
?
-
-
structure-activity relationship, overview
-
-
?
additional information
?
-
-
perinatal copper deficiency in rat pups inhibits the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
?
additional information
?
-
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(+)-p-[1-(p-tert-butylphenyl)-2-oxo-4-pyrrolidinyl]methoxybenzoic acid
-
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
-
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
-
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
-
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
-
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
-
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
-
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
1'-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)-6-morpholin-4-yl-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
7% inhibition at 0.01 mM
1'-(10H-phenothiazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
16% inhibition at 0.01 mM
1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
51% inhibition at 0.005 mM
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
-
i.e. CP-640186 or bispiperidylcarboxamide derivative I with a tricyclic hydrophobic core, shows inhibition of both ACC1 and ACC2
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
44% inhibition at 0.01 mM
1'-[(4,8-dimethoxyquinolin-2-yl)carbonyl]-6-(1H-1,2,4-triazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
complete inhibition at 0.005 mM
1'-[(4,8-dimethoxyquinolin-2-yl)carbonyl]-6-[(1-methyl-1H-pyrazol-5-yl)amino]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
complete inhibition at 0.005 mM
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
1,1,1-trifluoro-2-methylpropan-2-yl 4-(4-[[2-amino-6-(trifluoromethyl)-1-benzothiophen-3-yl]carbonyl]piperazin-1-yl)piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1-((2S)-1-((2-(4-(3-(cyclopropylmethoxy)phenoxy)phenyl)-1,3-oxazol-5-yl)oxy)propan-2-yl)urea
selective and potent ACC1 inhibitor, shows acceptable solubility and CYP inhibition profiles. Oral administration significantly reduces the concentration of malonyl-CoA in HCT-116 xenograft tumors at doses of more than 30 mg/kg
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
-
1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
-
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
-
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
-
-
1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
-
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
-
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
-
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
-
1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
-
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
-
1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
-
1-ethyl-3-[3-[(4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1-benzothiophen-2-yl]urea
-
-
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
-
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
-
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
-
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
-
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
-
1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
-
1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
-
-
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea
-
-
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
-
-
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
-
-
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
2'-tert-butyl-1-(1H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one
-
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]-methyl)cyclohexyl]methyl]carbamate
-
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
2-(4-Chlorophenoxy)-2-methylpropionate
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
-
2-methoxy-N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
-
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid
2-methyl-N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)propanamide
-
-
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
-
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
-
-
3,3,14,14-tetramethylhexadecanedioic acid
-
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
-
-
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
4-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-1-(4-propoxyphenyl)piperazine
-
4-bromo-2,3-dioxobutyl-CoA
-
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
-
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
-
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
-
-
4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
-
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
5-(tetradecyloxy)-2-furancarboxylic acid
-
5-(tetradecyloxy)-2-furoic acid
5-(tetradecyloxy)-2-furoyl-CoA
-
-
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
-
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
-
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
5-tetradecyloxy-2-furoic acid
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
5-[1'-[(1-cyclopropyl-4-methoxy-3-methyl-1H-indol-6-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]pyridine-3-carboxylic acid
-
-
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
-
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
6-morpholin-4-yl-1'-(10H-phenothiazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
64% inhibition at 0.01 mM
6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
-
Acyl carrier protein
-
acylated derivatives, acyls with chain lengths from C6:0 to C20:1 are inhibitory, 0.04 mM results in 60-70% inhibition, complete inhibition not achieved even with very high concentrations
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
-
-
beta,beta'-Tetramethyl-substituted hexadecanedioic acid
-
i.e. MEDICA, dead-end inhibitor
beta,beta,beta',beta'-tetramethylhexadecanoic acid
-
BODIPY-soraphen A
a soraphen A derivative, shows high activity against ACC2, synthesis, overview. BODIPY-soraphen A directly binds to the BC domain of the ACC enzyme by causing a 10°C increase in thermal stability of the protein using a differential scanning calorimetry assay
BRCA1 protein
-
BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction
-
chloroacetylated biotin derivative
-
80% inhibition
-
Co2+
26% residual activity at 10-15 mM
CoASH
inhibits acetyl-CoA carboxylase activity 50 to 57% and propionyl-CoA carboxylase activity 11 to 13%
coenzyme A-carboxybiotin
-
coenzyme A is covalently attached to carboxybiotin, bisubstrate inhibitor
CP-640188
-
molecular inhibitory mechanism, binding structure
cyclohexyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
cyclopentyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
diisopropyl phosphorofluoridate
-
-
dithiothreitol
dithiothreitol inhibits the enzyme slightly, by approximately 12%, at a final concentration of 5 to 10 mM
Double-stranded DNA
-
inhibits catalysis by the carboxyltransferase subunit of acetyl-CoA carboxylase by complex formation and influencing the active site structure, while substrates malonyl-CoA and biocytin inhibit DNA-carboxyltransferase complex formation, overview. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
DTNB
-
complete inhibition at 0.02 mM
DTT
5-10 mM, 12% inhibition
ethyl (1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)carbamate
-
-
ethyl (1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
-
-
ethyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclo-hexyl]-methyl]carbamate
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
ethyl(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
-
-
ethylene glycol monomethyl ether
-
-
FOP herbicides
-
IC50 of 0.005-0.02 mM
-
H2O2
-
dark enzyme completely inhibited at 2 mM, slight activity observed with light enzyme
HCO3-
-
competitive inhibition versus phosphate
heparin
-
the DNA mimic inhibits the reaction catalyzed by carboxyltransferase in a competitive manner with respect to both malonyl-CoA and biocytin. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
High molecular weight protein
-
from rat liver cytosol, approximately 1500000-2000000 Da
-
long-chain acyl-CoA thioesters
-
-
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
-
-
methyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
-
-
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
-
-
N-(1-(2'-methyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(2,2'-dimethyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(2-methyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4'-[4-(benzyloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4-[6-(3-phenoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
-
N-(1-(4-[6-(4-ethoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)-1H-pyrazole-4-carboxamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)butanamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)cyclopropanecarboxamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)pentanamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)propanamide
-
-
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[2-methyl-3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[2-methyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
N-(1-methyl-3-[2-[4-(2-methylpropoxy)-2-nitrophenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
-
N-(1-[4'-(3-butoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(3-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(3-methoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(3-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
-
-
N-(1-[4'-(4-benzylphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(4-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(4-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)butanamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)pentanamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
-
N-(1-[4'-(4-propylphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(2,6-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
-
N-(3,4-dimethoxyphenyl)acetamide
N-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
N-(3-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-(2-chloro-4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-(hydroxymethyl)-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-amino-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-bromo-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-cyano-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-fluoro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-formyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-vinyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
-
moderate selective isoform ACC2 inhibitor
N-(3-[cis-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(4-hydroxy-3-methoxycyclohexa-2,5-dien-1-yl)acetamide
N-(4-hydroxy-3-methoxyphenyl)acetamide
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
-
N-3-[2-[2-chloro-(4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-tert-butyl-4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxamide
-
-
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
-
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
-
N-[(2R)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
-
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
-
-
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
N-[1'-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)-4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
4% inhibition at 0.01 mM
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-N-methylbutanamide
-
83% inhibition at 0.01 mM
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]butanamide
-
-
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
-
-
N-[1-(4-(6-[4-(benzyloxy)phenoxy]pyridin-3-yl)phenyl)ethyl]acetamide
-
-
N-[1-(4-(6-[4-(propan-2-yloxy)phenoxy]pyridin-3-yl)phenyl)ethyl]acetamide
-
-
N-[1-methyl-3-(2-phenoxy-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(4-propoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
-
-
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
-
-
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(dimethylamino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(E)-(hydroxyimino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(methoxymethyl)amino]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
-
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
-
-
N-[4-oxo-1'-(10H-phenothiazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
48% inhibition at 0.01 mM
N-[4-oxo-1'-(10H-phenoxazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
-
NaCl
-
30% inhibition at 100 mM
p-chloromercuribenzoate
-
-
palmitoyl-1,N6-etheno-CoA
-
-
Palmitoyl-4'-phosphopantetheine
-
-
palmitoyl-acyl carrier protein
5 min, 55% inhibition, decrease of inhibition thereafter. Enzyme exhibits a significant hysteresis in presence of palmitoyl-acyl carrier protein. Allosteric inhibitor, the pantothenic acid moiety of palmitoyl-acyl carrier protein is responsible for the inhibition. Competitive with respect to acetyl-CoA
-
palmitoyl-dephospho-CoA
-
-
Palmitoyl-inosino-CoA
-
-
Phenyl chloromercuribenzoate
-
-
phosphoenolpyruvate
-
weak
PII protein
-
recombinant Arabidopsis PII protein inhibits chloroplastic ACCase activity dose-dependently and noncompetitively via binding to its BCCP subunit, and this is completely reversed in the presence of 2-oxoglutarate, pyruvate, or oxaloacetate. PII protein decreases the Vmax of the ACCase reaction without altering the Km for acetyl-CoA
-
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-5-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate maleate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
propionyl-CoA
-
below 0.1 mM almost as effective as substrate as acetyl-CoA, inhibitory at higher concentrations
pseudopeptide pyrrolidinedione inhibitor
-
single-stranded DNA
-
inhibits the reaction catalyzed by carboxyltransferase in a competitive manner with respect to both malonyl-CoA and biocytin. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
tepraloxydim
a herbicide, binding mode and structure-activity relationship, molecular inhibition mechanism, overview
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]-methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)methyl]-carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]-carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)-methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]-cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
-
-
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclo-hexyl]methyl]carbamate acetate
-
-
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]-methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]-methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]-methyl)cyclohexyl]methyl]carbamate
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone
-
-
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
-
-
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
-
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
-
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
-
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
-
-
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
-
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 4 nM, for the wild-type enzyme in crude extract 11 nM
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 91 nM
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
-
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 37 nM, for the wild-type enzyme in crude extract 288 nM
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 540 nM
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
-
IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
-
IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype
2-(4-Chlorophenoxy)-2-methylpropionate
-
-
2-(4-Chlorophenoxy)-2-methylpropionate
-
-
2-(4-Chlorophenoxy)-2-methylpropionate
-
-
2-(4-Chlorophenoxy)-2-methylpropionate
-
-
2-(4-Chlorophenoxy)-2-methylpropionate
-
-
2-ethylhexanoic acid
-
-
2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid
-
-
2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid
-
-
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
-
IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
-
IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
-
-
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
-
-
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
-
-
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
-
-
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
-
IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
-
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5-(tetradecyloxy)-2-furoic acid
an ACC1 inhibitor e.g. in beta cells
5-(tetradecyloxy)-2-furoic acid
-
a hypolipidemic agent
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
-
IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
-
IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
-
IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
-
IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
-
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
-
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC50 for the purified recombinant subunits AccA and AccD is 1 nM, for the wild-type enzyme in crude extract 8 nM
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC50 for the purified recombinant subunits AccA and AccD is 50 nM
ADP
-
-
Alloxydim
-
-
AMP
-
-
andrimid
-
-
andrimid
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 13 nM
andrimid
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 305 nM
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
i.e. CP-640186
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
-
ATP
above 2.0 mM
ATP
an excess of ATP (2.0 mM) has an inhibitory effect on the enzymatic activities
ATP
-
competitive inhibition versus ADP
Avidin
-
general inhibitor of ACCase activity
-
Avidin
reversible by addition of biotin
-
Avidin
-
complete inhibition at 1 nM
-
Avidin
-
biotin prevents inhibition
-
citrate
3 mM, more than 50% inhibition
citrate
citrate inhibits the enzyme activity by more than 50% at concentrations of 3 mM
citrate
-
9686 enzyme: below 3 mM no effect, inhibition above. Wayne enzyme: slight stimulation up to 5 mM, strong inhibition above
citrate
-
stimulates at 2 mM, inhibits at higher concentrations
Clethodim
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Clodinafop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Clodinafop
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
CoA
1 mM, 11-13% inhibition of acetyl-CoA carboxylase
CoA
-
inhibition requires the presence of MgATP2-, but is independent of phosphorylation of the enzyme, the effect is complete in about 5 min and is associated with depolymerization of acetyl-CoA carboxylase, half-maximal inhibition at 0.04 mM CoA, inhibition is partially reversed by incubation with citrate and more fully overcome by treatment of the enzyme with the insulin-stimulated acetyl-CoA carboxylase
CP-640186
-
inhibition of both isozymes Acc1 and Acc2, an anthracene fluorophore, probably binds to the biotin binding site
CP-640186
-
herbicide, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure, binds to the biotin binding site
CP-640186
-
an anthracene fluorophore, probably binds to the biotin binding site
CP-640186
-
herbicide, IC50 is 0.008 mM, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure involving Leu1705 and Val1967, binds to the biotin binding site
Cycloxydim
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Diclofop
-
-
Diclofop
Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10 -
Diclofop
herbicide, molecular inhibition mechanism, active site binding structure involving Tyr1738 and Phe1956, binding induces large conformational changes in the enzyme
fatty acyl-CoA ester
-
fenoxaprop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
fenoxaprop
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
fenoxaprop
-
a specific inhibitor of the cytosolic ACCase, does not affect the activity of chloroplast ACCase
Fluazifop
-
-
Fluazifop
Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10 -
Fluazifop
slight inhibition
Fluazifop
-
ACCase2 isoform is about 1/150 as sensitive as ACCase1 isoform
Haloxyfop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Haloxyfop
Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10 -
Haloxyfop
-
competitive inhibition
Haloxyfop
herbicide, molecular inhibition mechanism, active site binding structure involving Tyr1738 and Phe1956, binding induces large conformational changes in the enzyme
Haloxyfop
-
herbicide, binding structure and inhibition mechanism, binds to an allosteric site
Haloxyfop
-
0.001 mM, 65-80% inhibition of acetyl-CoA carboxylase I, less than 50% inhibition of acetyl-CoA carboxylase II
K+
-
K+
the enzyme shows less than 50% activity when the concentration is higher than 40 mM
long-chain fatty acids
-
-
long-chain fatty acids
-
potent feedback inhibition
long-chain fatty acids
-
potent feedback inhibition
long-chain fatty acids
-
-
long-chain fatty acids
-
potent feedback inhibition
malonyl-CoA
0.5 mM, 50-57% inhibition of acetyl-CoA carboxylase
malonyl-CoA
inhibits acetyl-CoA carboxylase activity 50 to 57% and propionyl-CoA carboxylase activity 11 to 13%
malonyl-CoA
-
product inhibition, competitive to acetyl-CoA
malonyl-CoA
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
malonyl-CoA
-
competitive inhibition versus acetyl-CoA
malonyl-CoA
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
malonyl-CoA
-
product inhibition, competitive to acetyl-CoA
malonyl-CoA
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
methylmalonyl-CoA
0.5 mM, 79% inhibition of acetyl-CoA carboxylase
methylmalonyl-CoA
60% inhibition at 0.5 mM; 79% inhibition at 0.5 mM
Mg2+
above 4.0 mM
Mg2+
an excess of Mg2+ (higher than 4.0 mM) has an inhibitory effect on the enzymatic activities
Mg2+
-
about 10 mM Mg2+ required for maximal activity, inhibition above 15 mM
Mg2+
-
at high concentrations
Mn2+
above 2.0 mM
Mn2+
an excess of Mn2+ (higher than 2.0 mM) has an inhibitory effect on the enzymatic activities
moiramide B
-
-
moiramide B
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, competitive with respect to malonyl-CoA, noncompetitive to biocytin, IC50 for the purified recombinant subunits AccA and AccD is 6 nM, for the wild-type enzyme in crude extract 15 nM
moiramide B
-
potent inhibitor
moiramide B
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 96 nM
moiramide B
-
potent inhibitor
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
potent and selective inhibitor
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(2,6-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(2,6-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(3,4-dimethoxyphenyl)acetamide
-
-
N-(3,4-dimethoxyphenyl)acetamide
-
-
N-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(4-hydroxy-3-methoxycyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(4-hydroxy-3-methoxycyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(4-hydroxy-3-methoxyphenyl)acetamide
-
-
N-(4-hydroxy-3-methoxyphenyl)acetamide
-
-
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
Na+
-
Na+
the enzyme shows less than 50% activity when the concentration is higher than 40 mM
NADH
-
-
oxaloacetate
-
-
palmitoyl-CoA
-
-
pinoxaden
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
pseudopeptide pyrrolidinedione inhibitor
-
-
-
pseudopeptide pyrrolidinedione inhibitor
-
-
-
pyridoxal 5'-phosphate
-
acetyl-CoA protects
pyridoxal phosphate
weak inhibitor; weak inhibitor
Quizalofop
-
-
Quizalofop
-
seed enzyme which carboxylates acety-CoA and propionyl-CoA has two separate active sites. One site binds either acetyl-CoA or propionyl-CoA and is inhibited by quizalofop. The other site is specific for acetyl-CoA and is much less inhibited by quizalofop. The leaf enzyme is not able to carboxylate propionyl-CoA and is insensitive to quizalofop
Quizalofop
-
ACCase2 isoform is about 1/2000 as sensitive as ACCase1 isoform. Mixed-type inhibition of ACCase1 isoform with respect to acetyl-CoA or ATP
Quizalofop
-
mesophyll chloroplast isoform reveals 1000fold greater sensitivity than non-mesophyll chloroplast isoform
S-carboxymethyl-CoA
-
-
Sethoxydim
-
Sethoxydim
Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10 -
Sethoxydim
-
0.01 mM, 65-80% inhibition of acetyl-CoA carboxylase I, less than 50% inhibition of acetyl-CoA carboxylase II
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
inhibitor reduces the levels of malonyl-CoA in endothelial cells
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
noncompetitive, binds to the BC domain
soraphen A
-
noncompetitive, binds to the BC domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
natural macrocyclic polyketid, inhibition mechanism, the inhibitor binds to an allosteric site in vicinity to the active site at the biotin carboxylase domain dimer interface causing only small coformational changes, binding structure and specificity
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
inhibits the enzyme allosterically by stabilizing a catalytically inactive conformation of the biotin carboxylase domain
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
noncompetitive, binds to the BC domain
succinyl-CoA
0.5 mM, 84% inhibition of acetyl-CoA carboxylase
succinyl-CoA
57% inhibition at 0.5 mM; 84% inhibition at 0.5 mM
sulfate
25 mM, more than 50% inhibition
sulfate
sulfate inhibits the enzyme activity by more than 50% at concentrations of 25 mM
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
-
-
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
-
-
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tralkoxydim
Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10 -
Trifop
-
-
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
-
-
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
-
-
additional information
-
resistance mechanisms, overview
-
additional information
-
herbicide mode and site of action
-
additional information
-
inhibitory and antibacterial potencies of pyrrolidine dione derivatives, overview
-
additional information
-
no inhibition by soraphen A
-
additional information
-
subunit AccB is a negative autoregulator of the accBC operon, overview
-
additional information
-
inhibitory and antibacterial potencies of pyrrolidine dione derivatives, overview
-
additional information
-
the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, overview, FOP herbicides are weak inhibitors of the human enzyme
-
additional information
-
ACCA is not affected by roscovitine
-
additional information
-
product inhibition analysis, inhibition patterns, overview
-
additional information
-
synthesis and enzymatic evaluation of potent inhibitors of acetyl-CoA carboxylases containing biphenyl or 3-phenyl pyridine cores
-
additional information
-
disubstituted (4-piperidinyl)-piperazine derivatives act as ACC1/2 non-selective inhibitors
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, effectively reduces ACC and fatty acid synthase activity and the triacylglycerol content of HepG2 cells, overview
-
additional information
-
inhibition of stearoyl-CoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells, overview
-
additional information
-
cereal crops are resistant to FOP herbicides, overview
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, FOP herbicides are weak inhibitors of the murine enzyme
-
additional information
-
synthesis of spiro[chroman-2,4-piperidin]-4-one derivatives as ACC inhibitors, overview
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview
-
additional information
-
cereal crops are resistant to FOÜ herbicides, overview
-
additional information
-
3,3,14,14-tetramethylhexanedecadienoic acid treatment if animals inhibits activity in liver by activation of AMP-activated protein kinase, no effect in muscle
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, FOP herbicides are weak inhibitors of the rat enzyme
-
additional information
-
no inhibition of the rat enzyme by pyrrolidine dione moiramide B, i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, and its derivatve 6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
additional information
-
activated AMP-activated protein kinase, AMPK, phosphorylates and inhibits acetyl-CoA carboxylase. ACC is inhibited in Cu-deficient cerebella
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC in liver microsomes with IC50 = 0.03 mg/ml. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview
-
additional information
-
FOP herbicides are weak inhibitors of the yeast enzyme
-
additional information
-
enzyme expression does not depend on light
-
additional information
-
inhibitory and antibacterial potencies of pyrrolidine dione derivatives, overview
-
additional information
-
no inhibition by soraphen A
-
additional information
no inhibition with Clethodim, Sethoxydim and Cethoxydim
-
additional information
-
no inhibition with Clethodim, Sethoxydim and Cethoxydim
-
additional information
-
no inhibition by soraphen A
-
additional information
-
addition of cations in presence of Mg2+ inhibits
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00029
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000157
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000155
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000248
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000869
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000434
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000842
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.000663 - 0.001
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
0.000505 - 0.00297
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
0.000178 - 0.001028
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
0.000789 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
0.000071 - 0.00191
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
0.00258 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
0.000273 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
0.00183 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
0.000246 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
0.000335 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
0.000486 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
0.000227 - 0.00936
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
0.000355 - 0.01
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
0.000231 - 0.00393
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
0.000244 - 0.000688
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000037 - 0.00457
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000258 - 0.00909
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000159 - 0.00921
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.00891
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
Rattus norvegicus
-
ACC1
0.00301
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
Rattus norvegicus
-
ACC1
0.00127
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
Rattus norvegicus
-
ACC1
0.000075
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000004 - 0.000091
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
0.000037 - 0.00054
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
0.001 - 0.00162
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
0.000163 - 0.0004
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.001 - 0.00132
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.000562
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000634 - 0.000641
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.00253
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00085
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00221
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000055
1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
Mus musculus
-
ACC1 and ACC2
0.000006
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000014
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000027
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000002
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000026
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000036
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000061
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.0012
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000303
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
Rattus norvegicus
-
ACC1
0.0000061 - 0.000031
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000075
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0000045 - 0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000074
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019 - 0.00003
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000017 - 0.000039
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000076 - 0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000031
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000062
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000027
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000058 - 0.000098
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
0.000045
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000041
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000012
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000117
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000038
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00000058
1-((2S)-1-((2-(4-(3-(cyclopropylmethoxy)phenoxy)phenyl)-1,3-oxazol-5-yl)oxy)propan-2-yl)urea
Homo sapiens
pH 7.5, 22°C
0.00017 - 0.00033
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000022 - 0.000051
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000043 - 0.000075
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000048 - 0.000087
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.00013 - 0.00023
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.0002 - 0.00036
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.0000049 - 0.000021
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
0.0000061 - 0.000025
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
0.0000059 - 0.000022
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
0.001864
1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000242
1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0000081 - 0.000041
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.000043 - 0.00041
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00002 - 0.00012
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000023 - 0.00035
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000014 - 0.000078
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000016 - 0.00011
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000027 - 0.00015
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
0.000049 - 0.00029
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000075 - 0.0003
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000131
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000184
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000052
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000068
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000076
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000102
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
Homo sapiens
-
ACC1/2
0.000169
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
Homo sapiens
-
ACC1/2
0.000126
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000115
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
Homo sapiens
-
ACC1/2
0.000076
1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000117
1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000127
1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000069
1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000042
1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000057
1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000032
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000037
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000021
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00003
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000055
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000033
1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000033
1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000059
1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00003
1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000169
1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000061
1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000049
1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000033
1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000036
1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000048
1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000105
1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000166 - 0.000492
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
0.000391 - 0.00401
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
0.000037 - 0.00015
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
0.000079 - 0.00065
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000207
1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000597
1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032 - 0.00023
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000033 - 0.00035
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000064 - 0.00051
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000051 - 0.00036
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000022 - 0.00028
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00004 - 0.00019
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000131
1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000144
1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000015 - 0.000076
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000009 - 0.000093
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000017
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000018 - 0.00012
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000012 - 0.00002
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.000249
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000766
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000045 - 0.00003
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.0000246
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000154
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000085 - 0.00016
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000013 - 0.000063
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
0.0000044 - 0.000048
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
0.000015 - 0.00016
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000109
1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000081
1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000049
1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000017 - 0.00015
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000017 - 0.00008
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000074
1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
ACC1/2
0.00015 - 0.003
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
0.0001
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000072
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000027
1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00007
1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000042
1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.0000084
1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00338
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.001
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00013
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.051 - 0.076
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
0.00184 - 0.00206
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.000718 - 0.000753
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000188 - 0.000214
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.038 - 0.054
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
0.0025 - 0.0057
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.000073
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
Homo sapiens
-
ACC1/2
0.558
3,3,14,14-tetramethylhexadecanedioic acid
Homo sapiens
-
0.000111 - 0.000216
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
0.000126 - 0.000172
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
0.0035 - 0.017
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
0.000067
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
Homo sapiens
-
ACC1/2
0.00075 - 0.0029
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
0.01
4-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-1-(4-propoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000169
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.000095
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.000151
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.00008
4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000023 - 0.000098
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.000061
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000086
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000034 - 0.000048
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.0011
5-(tetradecyloxy)-2-furoyl-CoA
Rattus norvegicus
-
pH 7.5, 37°C, partially purified native enzyme
0.000126 - 0.00146
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
0.000841 - 0.00428
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
0.0009 - 0.0046
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
0.0018 - 0.028
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000012 - 0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000019 - 0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000051 - 0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000065 - 0.000104
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000026
5-methoxy-1'-{[2-(pyridin-2-yl)-1H-benzimidazol-6-yl]carbonyl}spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000016 - 0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
0.000011 - 0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
0.0035 - 0.0043
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.000054
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.0000097
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000975
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.00135
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000182
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000366
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000036
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000022 - 0.000048
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000236
6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.0000064 - 0.000013
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.00183
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00139 - 0.00213
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000001 - 0.00005
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
0.000099
6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000059
7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000208
7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000013 - 0.000305
andrimid
0.00006
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000325
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.000091
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000095
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000161
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000239
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000121
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.00007 - 0.00091
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
0.000066 - 0.002112
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
0.00024 - 0.01157
Clethodim
0.00006 - 0.008
CP-640186
0.000076
cyclohexyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000244
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000052
cyclopentyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00127 - 0.0482
diclofop acid
0.000055
ethyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0014 - 0.008
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.03 - 0.031
ethyl(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
0.0001
fenoxaprop-P-ethyl
Dinebra chinensis
-
at 30°C
0.005 - 0.02
FOP herbicides
Toxoplasma gondii
-
IC50 of 0.005-0.02 mM
-
0.0017 - 0.075
haloxyfop acid
0.017
malonyl-CoA
Homo sapiens
-
0.000102
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
Homo sapiens
-
ACC1/2
0.000175
methyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00025 - 0.0039
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
0.00162
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
Homo sapiens
-
isozyme ACC2
0.000006 - 0.000096
moiramide B
0.000089 - 0.03
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.03
N-(1-(4'-[4-(benzyloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.000035 - 0.000113
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.000017 - 0.000033
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
0.00616
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000018
N-(1-methyl-3-[2-[2-methyl-3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000009
N-(1-methyl-3-[2-[2-methyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000014
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000013
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00021
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00013
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00038
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00029
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.0000044 - 0.00019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00007
N-(1-methyl-3-[2-[4-(2-methylpropoxy)-2-nitrophenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00001
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00081
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000057
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000067
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00037
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00035 - 0.01948
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000054 - 0.000193
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
0.000012 - 0.000013
N-(1-[4'-(3-butoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.00102 - 0.00858
N-(1-[4'-(3-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000373 - 0.03
N-(1-[4'-(3-methoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000016 - 0.000041
N-(1-[4'-(3-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000036 - 0.000609
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
0.000039 - 0.000945
N-(1-[4'-(4-benzylphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000119 - 0.00163
N-(1-[4'-(4-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000007 - 0.000014
N-(1-[4'-(4-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.000014 - 0.000017
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
0.00277 - 0.03
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)butanamide
0.000296 - 0.00055
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
0.03
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)pentanamide
0.000047 - 0.000202
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
0.000081 - 0.000114
N-(1-[4'-(4-propylphenoxy)biphenyl-4-yl]ethyl)acetamide
0.0000175
N-(2,6-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
Rattus norvegicus
-
ACC1
0.000348 - 0.000811
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
0.000016 - 0.000035
N-(3,4-dimethoxyphenyl)acetamide
0.000164 - 0.00022
N-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
0.000061
N-(3-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-1-methylprop-2-yn-1-yl)acetamide
Mus musculus
-
-
0.001
N-(3-[2-[2-(hydroxymethyl)-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.0158
N-(3-[2-[2-amino-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000035
N-(3-[2-[2-bromo-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000069
N-(3-[2-[2-chloro-4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000012
N-(3-[2-[2-chloro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000029
N-(3-[2-[2-chloro-4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000019
N-(3-[2-[2-chloro-4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000034
N-(3-[2-[2-chloro-4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00014
N-(3-[2-[2-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000042
N-(3-[2-[2-cyano-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000011
N-(3-[2-[2-fluoro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00055
N-(3-[2-[2-formyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00026
N-(3-[2-[2-vinyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000026
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000027
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000016
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000005 - 0.000027
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.000013
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000007
N-(3-[2-[4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000016
N-(3-[2-[4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00027 - 0.025
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.00265 - 0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.0021 - 0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.0007 - 0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
0.00063 - 0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
N-(3-[cis-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004 - 0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.00019 - 0.013
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.000011 - 0.000042
N-(4-hydroxy-3-methoxycyclohexa-2,5-dien-1-yl)acetamide
0.000102 - 0.000151
N-(4-hydroxy-3-methoxyphenyl)acetamide
0.000259 - 0.01
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
0.000013
N-3-[2-[2-chloro-(4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000119
N-tert-butyl-4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxamide
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00004 - 0.000724
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
0.000024 - 0.000386
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
0.03
N-[(2R)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0078 - 0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00006 - 0.0105
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
0.0001 - 0.03
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0002 - 0.00675
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.000015 - 0.00114
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00008 - 0.0008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.00006 - 0.01
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
0.000006
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]butanamide
Mus musculus
-
-
0.00014 - 0.000268
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
0.00196
N-[1-methyl-3-(2-phenoxy-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00015
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00055
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000076
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00011
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000004
N-[1-methyl-3-[2-(4-propoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00405
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00128 - 0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
0.00007 - 0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
0.00131
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00132
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00085
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000037
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.0017
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00047
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00034
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-[2-[(dimethylamino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00057
N-[3-[2-[2-[(E)-(hydroxyimino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-[2-[(methoxymethyl)amino]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.0007 - 0.02
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
0.00021 - 0.03
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.00014 - 0.0079
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0012 - 0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.0002 - 0.00452
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.00008 - 0.0079
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.0067 - 0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00019 - 0.0032
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.00067 - 0.017
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
0.000101
N-[4-oxo-1'-(10H-phenoxazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
Mus musculus
-
-
0.00015
PII protein
Arabidopsis thaliana
-
apparent value, in 100 mM Tricine (pH 8.2), at 30°C
-
0.000411
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
Homo sapiens
-
ACC1/2
0.000028
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-5-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate maleate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00006
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000008 - 0.000033
pseudopeptide pyrrolidinedione inhibitor
-
0.008
tall oil fatty acid
Homo sapiens
-
-
0.0029
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000099 - 0.001
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
0.000024
tert-butyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0025
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00078
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00057 - 0.0023
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
0.0058 - 0.0083
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
0.0045 - 0.0066
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00024
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000089 - 0.00078
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00073 - 0.0053
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00023 - 0.0023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0017
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00069 - 0.0043
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00033
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.001
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0038
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00021
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00069
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0013 - 0.013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00021
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0011
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00024 - 0.0013
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.000052
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00063 - 0.0045
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00011 - 0.0012
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.01
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00068
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0063
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00021 - 0.0158
tralkoxydim
0.0036
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000693
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone
Homo sapiens
-
ACC1/2
0.03
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
Homo sapiens
-
isozyme ACC2
0.0265
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
Homo sapiens
-
isozyme ACC2
0.0099
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0017
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000663
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
Rattus norvegicus
-
ACC1
0.001
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
Homo sapiens
-
above, ACC2
0.000505
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
Homo sapiens
-
ACC2
0.00297
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
Rattus norvegicus
-
ACC1
0.000178
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.001028
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000789
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000071
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00191
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00258
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000273
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.00183
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000246
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000335
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000486
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000227
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00936
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000355
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000231
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00393
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000244
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000688
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000037
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00457
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000258
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00909
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000159
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00921
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000004
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 4 nM
0.000011
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the wild-type enzyme in crude extract 11 nM
0.000091
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 91 nM
0.000037
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 37 nM
0.000288
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
, for IC50 for the wild-type enzyme in crude extract 288 nM
0.00054
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 540 nM
0.001
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
above, ACC2
0.00162
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000163
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0004
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.001
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
above, ACC2
0.00132
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000634
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000641
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000061
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000031
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0000045
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00003
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000017
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000039
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000076
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000058
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000098
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00017
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00033
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000051
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000043
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000075
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000048
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000087
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.00013
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00023
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0002
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.00036
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000049
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000021
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000061
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000025
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000059
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.0000081
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000041
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000043
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00041
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00002
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00012
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000023
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00035
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000014
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000078
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000016
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00011
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000027
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000049
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00029
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000075
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.0003
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000166
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000492
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000391
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00401
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000037
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000079
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00065
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000032
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00023
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000033
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00035
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000064
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00051
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000051
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00036
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00028
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00004
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00019
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000015
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000076
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000009
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000093
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000018
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00012
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000012
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.00002
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.0000045
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.00003
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000085
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00016
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000013
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000063
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000044
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000048
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000015
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00016
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000017
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000017
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00008
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.003
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.051
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
Setaria viridis
-
IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype
0.076
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
Eleusine indica
-
IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype
0.00184
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.00206
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000718
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000753
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000188
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000214
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.038
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype
0.054
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype
0.0025
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype
0.0057
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype
0.000111
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
Homo sapiens
-
ACC2
0.000216
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
Rattus norvegicus
-
ACC1
0.000126
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
Homo sapiens
-
ACC2
0.000172
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
Rattus norvegicus
-
ACC1
0.0035
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype
0.017
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype
0.00075
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0029
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000023
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000098
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.000034
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000048
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.000126
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.00146
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.000841
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.00428
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.0009
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
Setaria viridis
-
IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype
0.0046
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
Eleusine indica
-
IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype
0.0018
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
Setaria viridis
-
IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype
0.028
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
Eleusine indica
-
IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000012
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000019
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000051
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000065
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000104
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000016
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Rattus norvegicus
-
ACC1
0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000011
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Rattus norvegicus
-
ACC1
0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.0035
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype
0.0043
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype
0.000022
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000048
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000064
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000013
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00139
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00213
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000001
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 1 nM
0.000008
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Escherichia coli
-
IC 50 for the wild-type enzyme in crude extract 8 nM
0.00005
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 50 nM
0.000013
andrimid
Escherichia coli
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 13 nM
0.000305
andrimid
Staphylococcus aureus
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 305 nM
0.00007
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00028
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00059
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00091
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000066
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
Homo sapiens
-
ACC1/2
0.002112
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
Homo sapiens
-
ACC1/2
0.00024
Clethodim
Lolium rigidum
-
wild type enzyme
0.00426
Clethodim
Lolium rigidum
-
mutant enzyme I1781L
0.00976
Clethodim
Lolium rigidum
-
mutant enzyme D2078G
0.01157
Clethodim
Lolium rigidum
-
mutant enzyme C2088A
0.00006
CP-640186
Homo sapiens
-
0.000092
CP-640186
Rattus norvegicus
-
ACC1
0.008
CP-640186
Saccharomyces cerevisiae
-
herbicide, IC50 is 0.008 mM, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure involving Leu1705 and Val1967, binds to the biotin binding site
0.00127
diclofop acid
Lolium rigidum
-
wild type enzyme
0.00767
diclofop acid
Lolium rigidum
-
mutant enzyme I1781L
0.0409
diclofop acid
Lolium rigidum
-
mutant enzyme D2078G
0.0482
diclofop acid
Lolium rigidum
-
mutant enzyme C2088A
0.0014
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.008
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.03
ethyl(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
Homo sapiens
-
ACC1
0.031
ethyl(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
Homo sapiens
-
ACC2
0.0017
haloxyfop acid
Lolium rigidum
-
wild type enzyme
0.0234
haloxyfop acid
Lolium rigidum
-
mutant enzyme I1781L
0.0735
haloxyfop acid
Lolium rigidum
-
mutant enzyme C2088A
0.075
haloxyfop acid
Lolium rigidum
-
mutant enzyme D2078G
0.00025
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0039
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000006
moiramide B
Escherichia coli
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, competitive with respect to malonyl-CoA, noncompetitive to biocytin, IC50 for the purified recombinant su
0.000096
moiramide B
Staphylococcus aureus
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 96 nM
0.000089
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.03
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.03
N-(1-(4'-[4-(benzyloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
above, ACC1
0.03
N-(1-(4'-[4-(benzyloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
above, ACC2
0.000035
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000113
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.000017
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000033
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.0000044
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00035
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.01948
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000054
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000193
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000012
N-(1-[4'-(3-butoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000013
N-(1-[4'-(3-butoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.00102
N-(1-[4'-(3-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.00858
N-(1-[4'-(3-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000373
N-(1-[4'-(3-methoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.03
N-(1-[4'-(3-methoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000016
N-(1-[4'-(3-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000041
N-(1-[4'-(3-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000036
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
Homo sapiens
-
ACC1
0.000609
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
Homo sapiens
-
ACC2
0.000039
N-(1-[4'-(4-benzylphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000945
N-(1-[4'-(4-benzylphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000119
N-(1-[4'-(4-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.00163
N-(1-[4'-(4-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000007
N-(1-[4'-(4-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000014
N-(1-[4'-(4-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000014
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000017
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.00277
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)butanamide
Homo sapiens
-
ACC1
0.03
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)butanamide
Homo sapiens
-
ACC2
0.000296
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
Homo sapiens
-
ACC1
0.00055
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
Homo sapiens
-
ACC2
0.03
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)pentanamide
Homo sapiens
-
ACC1
0.03
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)pentanamide
Homo sapiens
-
ACC2
0.000047
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000202
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.000081
N-(1-[4'-(4-propylphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000114
N-(1-[4'-(4-propylphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000348
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000811
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000016
N-(3,4-dimethoxyphenyl)acetamide
Homo sapiens
-
ACC2
0.000035
N-(3,4-dimethoxyphenyl)acetamide
Rattus norvegicus
-
ACC1
0.000164
N-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
Homo sapiens
-
ACC2
0.00022
N-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
Rattus norvegicus
-
ACC1
0.000005
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000027
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00027
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0027
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.017
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.025
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00265
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0021
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00063
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.012
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.012
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.013
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000011
N-(4-hydroxy-3-methoxycyclohexa-2,5-dien-1-yl)acetamide
Homo sapiens
-
ACC2
0.000042
N-(4-hydroxy-3-methoxycyclohexa-2,5-dien-1-yl)acetamide
Rattus norvegicus
-
ACC1
0.000102
N-(4-hydroxy-3-methoxyphenyl)acetamide
Rattus norvegicus
-
ACC1
0.000151
N-(4-hydroxy-3-methoxyphenyl)acetamide
Homo sapiens
-
ACC2
0.000259
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.01
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
Homo sapiens
value above, pH and temperature not specified in the publication
0.00004
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000724
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000024
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000386
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.0078
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0099
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00006
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0006
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0023
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0105
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0001
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00092
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0018
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0026
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00675
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000015
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00003
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00017
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00114
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00036
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00006
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00038
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.01
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
IC50 above 0.01 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
Homo sapiens
-
ACC1
0.000268
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
Homo sapiens
-
ACC2
0.00128
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00007
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.014
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.003
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0074
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.02
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00021
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00075
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0021
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0011
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0079
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00178
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0026
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00452
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00008
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0011
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0079
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0067
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0127
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00062
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0019
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0032
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00067
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0057
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.011
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.017
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000008
pseudopeptide pyrrolidinedione inhibitor
Klebsiella pneumoniae
-
pH 8, 20°C
-
0.000033
pseudopeptide pyrrolidinedione inhibitor
Acinetobacter baumannii
-
pH 8, 20°C
-
0.000099
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.001
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00057
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0023
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0058
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0083
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0045
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0066
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000089
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00078
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00073
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0053
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00069
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0043
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00024
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0013
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00063
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0045
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00011
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0012
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00021
tralkoxydim
Lolium rigidum
-
wild type enzyme
0.00353
tralkoxydim
Lolium rigidum
-
mutant enzyme I1781L
0.0112
tralkoxydim
Lolium rigidum
-
mutant enzyme D2078G
0.0158
tralkoxydim
Lolium rigidum
-
mutant enzyme C2088A
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.